TY - JOUR
T1 - Targeting interleukin-β by plant-derived natural products
T2 - Implications for the treatment of atherosclerotic cardiovascular disease
AU - Vahdat-Lasemi, Fatemeh
AU - Aghaee-Bakhtiari, Seyed Hamid
AU - Tasbandi, Aida
AU - Jaafari, Mahmoud Reza
AU - Sahebkar, Amirhossein
PY - 2021/10
Y1 - 2021/10
N2 - Inflammation is the main contributing factor to atheroma formation in atherosclerosis. Interleukin-1 beta (IL-1β) is an inflammatory mediator found in endothelial cells and resident leukocytes. Canakinumab is a selective monoclonal antibody against IL-1β which attenuates inflammation and concurrently precipitates fatal infections and sepsis. Natural products derived from medicinal plants, herbal remedy and functional foods are widely used nowadays. Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1β suppression. In this review, we tried to document findings that used medicinal plants and plant-based natural products for treating atherosclerosis and its related diseases through the suppression of IL-1β.
AB - Inflammation is the main contributing factor to atheroma formation in atherosclerosis. Interleukin-1 beta (IL-1β) is an inflammatory mediator found in endothelial cells and resident leukocytes. Canakinumab is a selective monoclonal antibody against IL-1β which attenuates inflammation and concurrently precipitates fatal infections and sepsis. Natural products derived from medicinal plants, herbal remedy and functional foods are widely used nowadays. Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1β suppression. In this review, we tried to document findings that used medicinal plants and plant-based natural products for treating atherosclerosis and its related diseases through the suppression of IL-1β.
KW - atherosclerosis
KW - inflammation
KW - interleukin-1 beta
KW - phytochemical
UR - http://www.scopus.com/inward/record.url?scp=85112373772&partnerID=8YFLogxK
U2 - 10.1002/ptr.7194
DO - 10.1002/ptr.7194
M3 - Review article
C2 - 34390063
AN - SCOPUS:85112373772
VL - 35
SP - 5596
EP - 5622
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 10
ER -