Targeting interleukin-β by plant-derived natural products: Implications for the treatment of atherosclerotic cardiovascular disease

Fatemeh Vahdat-Lasemi, Seyed Hamid Aghaee-Bakhtiari, Aida Tasbandi, Mahmoud Reza Jaafari, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review

Abstract

Inflammation is the main contributing factor to atheroma formation in atherosclerosis. Interleukin-1 beta (IL-1β) is an inflammatory mediator found in endothelial cells and resident leukocytes. Canakinumab is a selective monoclonal antibody against IL-1β which attenuates inflammation and concurrently precipitates fatal infections and sepsis. Natural products derived from medicinal plants, herbal remedy and functional foods are widely used nowadays. Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1β suppression. In this review, we tried to document findings that used medicinal plants and plant-based natural products for treating atherosclerosis and its related diseases through the suppression of IL-1β.

Original languageEnglish
Pages (from-to)5596-5622
Number of pages27
JournalPhytotherapy Research
Volume35
Issue number10
DOIs
Publication statusPublished - Oct 2021

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