Targeting Glycoside Hydrolases and Central Carbon Metabolism to Disrupt Burkholderia pseudomallei Pathogenesis

Research output: ThesisDoctoral Thesis

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Abstract

The processes of carbohydrate metabolism are important for virulence in many heterotrophic bacterial pathogens. Carbohydrate-active enzymes (CAZymes) such as glycoside hydrolases (GHs) may therefore provide novel antimicrobial targets. Burkholderia pseudomallei is the causative agent of melioidosis, a disease characterized by severe pneumonia and septicaemia. Despite B.pseudomallei encoding for 35 GHs, only a few have been characterized. The aim of this study was to investigate the role of four putative GHs encoded by the genes bpsl0500, bpss0671, bpsl0611, bpss0159 and a Class II fructose-1,6-bisphosphate aldolase, encoded by bpsl0798, by the generation and characterisation of mutant strains.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Sarkar-Tyson, Mitali, Supervisor
  • Debowski, Aleksandra, Supervisor
  • Stubbs, Keith, Supervisor
  • Titball, Richard W., Supervisor, External person
Thesis sponsors
Award date29 May 2023
DOIs
Publication statusUnpublished - 2023

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