Targeted treatment for osteoarthritis: drugs and delivery system

Liwei Mao, Wei Wu, Miao Wang, Jianmin Guo, Hui Li, Shihua Zhang, Jiake Xu, Jun Zou

Research output: Contribution to journalArticlepeer-review

Abstract

The management of osteoarthritis (OA) is a clinical challenge due to the particular avascular, dense, and occluded tissue structure. Despite numerous clinical reports and animal studies, the pathogenesis and progression of OA are still not fully understood. On the basis of traditional drugs, a large number of new drugs have been continuously developed. Intra-articular (IA) administration for OA hastens the development of targeted drug delivery systems (DDS). OA drugs modification and the synthesis of bioadaptive carriers contribute to a qualitative leap in the efficacy of IA treatment. Nanoparticles (NPs) are demonstrated credible improvement of drug penetration and retention in OA. Targeted nanomaterial delivery systems show the prominent biocompatibility and drug loading-release ability. This article reviews different drugs and nanomaterial delivery systems for IA treatment of OA, in an attempt to resolve the inconsonance between in vitro and in vivo release, and explore more interactions between drugs and nanocarriers, so as to open up new horizons for the treatment of OA.

Original languageEnglish
Pages (from-to)1861-1876
Number of pages16
JournalDrug Delivery
Volume28
Issue number1
DOIs
Publication statusPublished - 2021

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