Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer

P. Beale; J. Beith; J. Carter; C. Dalrymple; A. Hamilton; R. Houghton; P. Russell; A. Brand; R. Jaworski; P. Harnett; G. Wain; A. Crandon; M. Cummings; K. Horwood; A. Obermair; D. Wyld; J. Nicklin; L. Perrin; B. Ward; M. Davy; C. Hall; T. Dodd; T. Healy; K. Pittman; D. Henderson; S. Hyde; J. Miller; J. Pierdes; P. Blomfield; D. Challis; R. Mcintosh; A. Parker; B. Brown; R. Rome; D. Allen; P. Grant; R. Laurie; M. Robbie; D. Healy; M.A. Merritt; A.C. Green; C.M. Nagle; P.M. Webb; D. Bowtell; G. Chenevix-Trench; P. Webb; A. Defazio; D. Gertig; N. Traficante; S. Moore; J. Hung; S. Fereday; K. Harrap; T. Sadkowsky; A. Mellon; R. Robertson; T. Vanden Bergh; J. Maidens; T. Jobling; T. Maniolitas; J. Mcnealage; P. Rogers; B. Susil; A. Veitch; J. Constable; S. Ping Tong; I. Robinson; I. Simpson; K. Phillips; D. Rischin; Paul Waring; M. Loughrey; N. O'Callaghan; B. Murray; V. Billson; S. Galloway; J. Pyman; M. Quinn; S. Bilic; L. Glavinas; A. Proietto; S. Braye; G. Otton; T. Bonaventura; J. Stewart; M. Friedlander; D. Bell; S. Baron-Hay; A. Ferrier; G. Gard; D. Nevell; B. Young; C. Camaris; R. Crouch; L. Edwards; N. Hacker; D. Marsden; G. Robertson; K. Nattress; Y.E. Chiew; A. Stenlake; H. Sullivan; B. Alexander; P. Ashover; S. Brown; T. Corrish; L. Green; L. Jackman; K. Martin; B. Ranieri; J. White; V. Jayde; L. Bowes; P. Mamers; T. Schmidt; H. Shirley; S. Viduka; H. Tran; I. Hammond; A. Mccartney; Y. Leung; I. Haviv; N. Zeps; P.G. Parsons; N. Hayward; D. Purdie; D. Whiteman; A. Green

doi:10.1002/ijc.23017

Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer

P. Beale, J. Beith, J. Carter, C. Dalrymple, A. Hamilton, R. Houghton, P. Russell, A. Brand, R. Jaworski, P. Harnett, G. Wain, A. Crandon, M. Cummings, K. Horwood, A. Obermair, D. Wyld, J. Nicklin, L. Perrin, B. Ward, M. DavyC. Hall, T. Dodd, T. Healy, K. Pittman, D. Henderson, S. Hyde, J. Miller, J. Pierdes, P. Blomfield, D. Challis, R. Mcintosh, A. Parker, B. Brown, R. Rome, D. Allen, P. Grant, R. Laurie, M. Robbie, D. Healy, M.A. Merritt, A.C. Green, C.M. Nagle, P.M. Webb, D. Bowtell, G. Chenevix-Trench, P. Webb, A. Defazio, D. Gertig, N. Traficante, S. Moore, J. Hung, S. Fereday, K. Harrap, T. Sadkowsky, A. Mellon, R. Robertson, T. Vanden Bergh, J. Maidens, T. Jobling, T. Maniolitas, J. Mcnealage, P. Rogers, B. Susil, A. Veitch, J. Constable, S. Ping Tong, I. Robinson, I. Simpson, K. Phillips, D. Rischin, Paul Waring, M. Loughrey, N. O'Callaghan, B. Murray, V. Billson, S. Galloway, J. Pyman, M. Quinn, S. Bilic, L. Glavinas, A. Proietto, S. Braye, G. Otton, T. Bonaventura, J. Stewart, M. Friedlander, D. Bell, S. Baron-Hay, A. Ferrier, G. Gard, D. Nevell, B. Young, C. Camaris, R. Crouch, L. Edwards, N. Hacker, D. Marsden, G. Robertson, K. Nattress, Y.E. Chiew, A. Stenlake, H. Sullivan, B. Alexander, P. Ashover, S. Brown, T. Corrish, L. Green, L. Jackman, K. Martin, B. Ranieri, J. White, V. Jayde, L. Bowes, P. Mamers, T. Schmidt, H. Shirley, S. Viduka, H. Tran, I. Hammond, A. Mccartney, Y. Leung, I. Haviv, N. Zeps, P.G. Parsons, N. Hayward, D. Purdie, D. Whiteman, A. Green

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Abstract

Chronic inflammation has been proposed as the possible causal mechanism that explains the observed association between certain risk factors, such as the use of talcum powder (talc) in the pelvic region and epithelial ovarian cancer. To address this issue we evaluated the potential role of chronic local ovarian inflammation in the development of the major subtypes of epithelial ovarian cancer. Factors potentially linked to ovarian inflammation were examined in an Australia-wide case–control study comprising 1,576 women with invasive and low malignant potential (LMP) ovarian tumours and 1,509 population-based controls. We confirmed a statistically significant increase in ovarian cancer risk associated with use of talc in the pelvic region (adjusted odds ratio 1.17, 95% CI: 1.01–1.36) that was strongest for the serous and endometrioid subtypes although the latter was not statistically significant (adjusted odds ratios 1.21, 95% CI 1.03–1.44 and 1.18, 95% CI 0.81–1.70, respectively). Other factors potentially associated with ovarian inflammation (pelvic inflammatory disease, human papilloma virus infection and mumps) were not associated with risk but, like others, we found an increased risk of endometrioid and clear cell ovarian cancer only among women with a history of endometriosis. Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only. We conclude that on balance chronic inflammation does not play a major role in the development of ovarian cancer.

Original language	English
Pages (from-to)	170-176
Journal	International Journal of Cancer
Volume	122
Issue number	1
DOIs	https://doi.org/10.1002/ijc.23017
Publication status	Published - 2008

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10.1002/ijc.23017

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Beale, P., Beith, J., Carter, J., Dalrymple, C., Hamilton, A., Houghton, R., Russell, P., Brand, A., Jaworski, R., Harnett, P., Wain, G., Crandon, A., Cummings, M., Horwood, K., Obermair, A., Wyld, D., Nicklin, J., Perrin, L., Ward, B., ... Green, A. (2008). Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer. International Journal of Cancer, 122(1), 170-176. https://doi.org/10.1002/ijc.23017

@article{fe4204054d9d4630bea91a2ff04d1f03,

title = "Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer",

abstract = "Chronic inflammation has been proposed as the possible causal mechanism that explains the observed association between certain risk factors, such as the use of talcum powder (talc) in the pelvic region and epithelial ovarian cancer. To address this issue we evaluated the potential role of chronic local ovarian inflammation in the development of the major subtypes of epithelial ovarian cancer. Factors potentially linked to ovarian inflammation were examined in an Australia-wide case–control study comprising 1,576 women with invasive and low malignant potential (LMP) ovarian tumours and 1,509 population-based controls. We confirmed a statistically significant increase in ovarian cancer risk associated with use of talc in the pelvic region (adjusted odds ratio 1.17, 95% CI: 1.01–1.36) that was strongest for the serous and endometrioid subtypes although the latter was not statistically significant (adjusted odds ratios 1.21, 95% CI 1.03–1.44 and 1.18, 95% CI 0.81–1.70, respectively). Other factors potentially associated with ovarian inflammation (pelvic inflammatory disease, human papilloma virus infection and mumps) were not associated with risk but, like others, we found an increased risk of endometrioid and clear cell ovarian cancer only among women with a history of endometriosis. Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only. We conclude that on balance chronic inflammation does not play a major role in the development of ovarian cancer.",

author = "P. Beale and J. Beith and J. Carter and C. Dalrymple and A. Hamilton and R. Houghton and P. Russell and A. Brand and R. Jaworski and P. Harnett and G. Wain and A. Crandon and M. Cummings and K. Horwood and A. Obermair and D. Wyld and J. Nicklin and L. Perrin and B. Ward and M. Davy and C. Hall and T. Dodd and T. Healy and K. Pittman and D. Henderson and S. Hyde and J. Miller and J. Pierdes and P. Blomfield and D. Challis and R. Mcintosh and A. Parker and B. Brown and R. Rome and D. Allen and P. Grant and R. Laurie and M. Robbie and D. Healy and M.A. Merritt and A.C. Green and C.M. Nagle and P.M. Webb and D. Bowtell and G. Chenevix-Trench and P. Webb and A. Defazio and D. Gertig and N. Traficante and S. Moore and J. Hung and S. Fereday and K. Harrap and T. Sadkowsky and A. Mellon and R. Robertson and {Vanden Bergh}, T. and J. Maidens and T. Jobling and T. Maniolitas and J. Mcnealage and P. Rogers and B. Susil and A. Veitch and J. Constable and {Ping Tong}, S. and I. Robinson and I. Simpson and K. Phillips and D. Rischin and Paul Waring and M. Loughrey and N. O'Callaghan and B. Murray and V. Billson and S. Galloway and J. Pyman and M. Quinn and S. Bilic and L. Glavinas and A. Proietto and S. Braye and G. Otton and T. Bonaventura and J. Stewart and M. Friedlander and D. Bell and S. Baron-Hay and A. Ferrier and G. Gard and D. Nevell and B. Young and C. Camaris and R. Crouch and L. Edwards and N. Hacker and D. Marsden and G. Robertson and K. Nattress and Y.E. Chiew and A. Stenlake and H. Sullivan and B. Alexander and P. Ashover and S. Brown and T. Corrish and L. Green and L. Jackman and K. Martin and B. Ranieri and J. White and V. Jayde and L. Bowes and P. Mamers and T. Schmidt and H. Shirley and S. Viduka and H. Tran and I. Hammond and A. Mccartney and Y. Leung and I. Haviv and N. Zeps and P.G. Parsons and N. Hayward and D. Purdie and D. Whiteman and A. Green",

year = "2008",

doi = "10.1002/ijc.23017",

language = "English",

volume = "122",

pages = "170--176",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Blackwell",

number = "1",

}

Beale, P, Beith, J, Carter, J, Dalrymple, C, Hamilton, A, Houghton, R, Russell, P, Brand, A, Jaworski, R, Harnett, P, Wain, G, Crandon, A, Cummings, M, Horwood, K, Obermair, A, Wyld, D, Nicklin, J, Perrin, L, Ward, B, Davy, M, Hall, C, Dodd, T, Healy, T, Pittman, K, Henderson, D, Hyde, S, Miller, J, Pierdes, J, Blomfield, P, Challis, D, Mcintosh, R, Parker, A, Brown, B, Rome, R, Allen, D, Grant, P, Laurie, R, Robbie, M, Healy, D, Merritt, MA, Green, AC, Nagle, CM, Webb, PM, Bowtell, D, Chenevix-Trench, G, Webb, P, Defazio, A, Gertig, D, Traficante, N, Moore, S, Hung, J, Fereday, S, Harrap, K, Sadkowsky, T, Mellon, A, Robertson, R, Vanden Bergh, T, Maidens, J, Jobling, T, Maniolitas, T, Mcnealage, J, Rogers, P, Susil, B, Veitch, A, Constable, J, Ping Tong, S, Robinson, I, Simpson, I, Phillips, K, Rischin, D, Waring, P, Loughrey, M, O'Callaghan, N, Murray, B, Billson, V, Galloway, S, Pyman, J, Quinn, M, Bilic, S, Glavinas, L, Proietto, A, Braye, S, Otton, G, Bonaventura, T, Stewart, J, Friedlander, M, Bell, D, Baron-Hay, S, Ferrier, A, Gard, G, Nevell, D, Young, B, Camaris, C, Crouch, R, Edwards, L, Hacker, N, Marsden, D, Robertson, G, Nattress, K, Chiew, YE, Stenlake, A, Sullivan, H, Alexander, B, Ashover, P, Brown, S, Corrish, T, Green, L, Jackman, L, Martin, K, Ranieri, B, White, J, Jayde, V, Bowes, L, Mamers, P, Schmidt, T, Shirley, H, Viduka, S, Tran, H, Hammond, I, Mccartney, A, Leung, Y, Haviv, I, Zeps, N, Parsons, PG, Hayward, N, Purdie, D, Whiteman, D & Green, A 2008, 'Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer', International Journal of Cancer, vol. 122, no. 1, pp. 170-176. https://doi.org/10.1002/ijc.23017

TY - JOUR

T1 - Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer

AU - Beale, P.

AU - Beith, J.

AU - Carter, J.

AU - Dalrymple, C.

AU - Hamilton, A.

AU - Houghton, R.

AU - Russell, P.

AU - Brand, A.

AU - Jaworski, R.

AU - Harnett, P.

AU - Wain, G.

AU - Crandon, A.

AU - Cummings, M.

AU - Horwood, K.

AU - Obermair, A.

AU - Wyld, D.

AU - Nicklin, J.

AU - Perrin, L.

AU - Ward, B.

AU - Davy, M.

AU - Hall, C.

AU - Dodd, T.

AU - Healy, T.

AU - Pittman, K.

AU - Henderson, D.

AU - Hyde, S.

AU - Miller, J.

AU - Pierdes, J.

AU - Blomfield, P.

AU - Challis, D.

AU - Mcintosh, R.

AU - Parker, A.

AU - Brown, B.

AU - Rome, R.

AU - Allen, D.

AU - Grant, P.

AU - Laurie, R.

AU - Robbie, M.

AU - Healy, D.

AU - Merritt, M.A.

AU - Green, A.C.

AU - Nagle, C.M.

AU - Webb, P.M.

AU - Bowtell, D.

AU - Chenevix-Trench, G.

AU - Webb, P.

AU - Defazio, A.

AU - Gertig, D.

AU - Traficante, N.

AU - Moore, S.

AU - Hung, J.

AU - Fereday, S.

AU - Harrap, K.

AU - Sadkowsky, T.

AU - Mellon, A.

AU - Robertson, R.

AU - Vanden Bergh, T.

AU - Maidens, J.

AU - Jobling, T.

AU - Maniolitas, T.

AU - Mcnealage, J.

AU - Rogers, P.

AU - Susil, B.

AU - Veitch, A.

AU - Constable, J.

AU - Ping Tong, S.

AU - Robinson, I.

AU - Simpson, I.

AU - Phillips, K.

AU - Rischin, D.

AU - Waring, Paul

AU - Loughrey, M.

AU - O'Callaghan, N.

AU - Murray, B.

AU - Billson, V.

AU - Galloway, S.

AU - Pyman, J.

AU - Quinn, M.

AU - Bilic, S.

AU - Glavinas, L.

AU - Proietto, A.

AU - Braye, S.

AU - Otton, G.

AU - Bonaventura, T.

AU - Stewart, J.

AU - Friedlander, M.

AU - Bell, D.

AU - Baron-Hay, S.

AU - Ferrier, A.

AU - Gard, G.

AU - Nevell, D.

AU - Young, B.

AU - Camaris, C.

AU - Crouch, R.

AU - Edwards, L.

AU - Hacker, N.

AU - Marsden, D.

AU - Robertson, G.

AU - Nattress, K.

AU - Chiew, Y.E.

AU - Stenlake, A.

AU - Sullivan, H.

AU - Alexander, B.

AU - Ashover, P.

AU - Brown, S.

AU - Corrish, T.

AU - Green, L.

AU - Jackman, L.

AU - Martin, K.

AU - Ranieri, B.

AU - White, J.

AU - Jayde, V.

AU - Bowes, L.

AU - Mamers, P.

AU - Schmidt, T.

AU - Shirley, H.

AU - Viduka, S.

AU - Tran, H.

AU - Hammond, I.

AU - Mccartney, A.

AU - Leung, Y.

AU - Haviv, I.

AU - Zeps, N.

AU - Parsons, P.G.

AU - Hayward, N.

AU - Purdie, D.

AU - Whiteman, D.

AU - Green, A.

PY - 2008

Y1 - 2008

N2 - Chronic inflammation has been proposed as the possible causal mechanism that explains the observed association between certain risk factors, such as the use of talcum powder (talc) in the pelvic region and epithelial ovarian cancer. To address this issue we evaluated the potential role of chronic local ovarian inflammation in the development of the major subtypes of epithelial ovarian cancer. Factors potentially linked to ovarian inflammation were examined in an Australia-wide case–control study comprising 1,576 women with invasive and low malignant potential (LMP) ovarian tumours and 1,509 population-based controls. We confirmed a statistically significant increase in ovarian cancer risk associated with use of talc in the pelvic region (adjusted odds ratio 1.17, 95% CI: 1.01–1.36) that was strongest for the serous and endometrioid subtypes although the latter was not statistically significant (adjusted odds ratios 1.21, 95% CI 1.03–1.44 and 1.18, 95% CI 0.81–1.70, respectively). Other factors potentially associated with ovarian inflammation (pelvic inflammatory disease, human papilloma virus infection and mumps) were not associated with risk but, like others, we found an increased risk of endometrioid and clear cell ovarian cancer only among women with a history of endometriosis. Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only. We conclude that on balance chronic inflammation does not play a major role in the development of ovarian cancer.

AB - Chronic inflammation has been proposed as the possible causal mechanism that explains the observed association between certain risk factors, such as the use of talcum powder (talc) in the pelvic region and epithelial ovarian cancer. To address this issue we evaluated the potential role of chronic local ovarian inflammation in the development of the major subtypes of epithelial ovarian cancer. Factors potentially linked to ovarian inflammation were examined in an Australia-wide case–control study comprising 1,576 women with invasive and low malignant potential (LMP) ovarian tumours and 1,509 population-based controls. We confirmed a statistically significant increase in ovarian cancer risk associated with use of talc in the pelvic region (adjusted odds ratio 1.17, 95% CI: 1.01–1.36) that was strongest for the serous and endometrioid subtypes although the latter was not statistically significant (adjusted odds ratios 1.21, 95% CI 1.03–1.44 and 1.18, 95% CI 0.81–1.70, respectively). Other factors potentially associated with ovarian inflammation (pelvic inflammatory disease, human papilloma virus infection and mumps) were not associated with risk but, like others, we found an increased risk of endometrioid and clear cell ovarian cancer only among women with a history of endometriosis. Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only. We conclude that on balance chronic inflammation does not play a major role in the development of ovarian cancer.

U2 - 10.1002/ijc.23017

DO - 10.1002/ijc.23017

M3 - Article

SN - 0020-7136

VL - 122

SP - 170

EP - 176

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 1

ER -

Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer

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