TY - JOUR
T1 - Tailored mesoporous silica nanoparticles for controlled drug delivery
T2 - Platform fabrication, targeted delivery, and computational design and analysis
AU - She, Xiaodong
AU - Chen, Lijue
AU - Yi, Zhifeng
AU - Li, Chengpeng
AU - He, Canzhong
AU - Feng, Chunfang
AU - Wang, Tao
AU - Shigdar, Sarah
AU - Duan, Wei
AU - Kong, Lingxue
N1 - Publisher Copyright:
© 2018 Bentham Science Publishers.
PY - 2018
Y1 - 2018
N2 - Mesoporous silica nanoparticles (MSNs) are exceptionally promising drug carriers for controlled drug delivery systems because their morphology, pore structure, pore volume and pore size can be well tailored to obtain certain drug release profiles. Moreover, they possess the ability to specifically transport and deliver anti-cancer drugs when targeting molecules are properly grafted onto their surface. MSNs based drug delivery systems have the potential to revolutionize cancer therapy. This review provides a comprehensive overview of the fabrication, modification of MSNs and their applications in tumour-targeted delivery. In addition, the characterization and analysis of MSNs with computer aided strategies were described. The existing issues and future prospective concerning the applications of MSNs as drug carriers for controlled drug delivery systems were discussed.
AB - Mesoporous silica nanoparticles (MSNs) are exceptionally promising drug carriers for controlled drug delivery systems because their morphology, pore structure, pore volume and pore size can be well tailored to obtain certain drug release profiles. Moreover, they possess the ability to specifically transport and deliver anti-cancer drugs when targeting molecules are properly grafted onto their surface. MSNs based drug delivery systems have the potential to revolutionize cancer therapy. This review provides a comprehensive overview of the fabrication, modification of MSNs and their applications in tumour-targeted delivery. In addition, the characterization and analysis of MSNs with computer aided strategies were described. The existing issues and future prospective concerning the applications of MSNs as drug carriers for controlled drug delivery systems were discussed.
KW - Computational design
KW - Controlled release
KW - Mesoporous silica nanoparticles
KW - Mesoporous silica nanoparticles (MSN)
KW - Nanocarriers
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85049647446&partnerID=8YFLogxK
U2 - 10.2174/1389557516666160505114814
DO - 10.2174/1389557516666160505114814
M3 - Review article
SN - 1389-5575
VL - 18
SP - 976
EP - 989
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 11
ER -