T-lymphoblastic proliferation and florid multifocal follicular dendritic cell proliferation occurring in hyaline-vascular Castleman disease in a patient with a possible familial predisposition

C. Leslie, M.V. Shingde, F. Kwok, M.A. Platten, Y. Tesfai, Benhur Amanuel, Dominic Spagnolo

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    Hyaline-vascular Castleman disease (HVCD) often presents as unicentric disease which is usually cured by surgical resection. Here, we report a case of a 23-year-old man with HVCD in the mediastinum, in which an apparently indolent T-lymphoblastic proliferation and extensive organoid proliferation of follicular dendritic cells were also present. The patient had no systemic involvement and no further disease at follow-up. In addition, there is a possible unique family history of HVCD. This case highlights an interesting combination of elements, mostly likely benign in nature. © 2013 Springer-Verlag Berlin Heidelberg.
    Original languageEnglish
    Pages (from-to)237-244
    JournalJournal of Hematopathology
    Issue number4
    Publication statusPublished - 2013


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