Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer

R. Sharma, M. Zucknick, Roslyn London, M. Kacevska, C. Liddle, S.J. Clarke

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

We aim to confirm the prognostic value of an inflammation-based prognostic score (the Glasgow Prognostic Score [GPS]) in advanced colorectal cancer,to explore a predictive pattern of plasma cytokines and their gene polymorphisms for clinical outcome, and to investigate which cytokines contribute to GPS. Inflammatory markers were measured at baseline in 52 patients with stage IV colorectal cancer. Germline DNA was genotyped for interleukin (IL)-1 beta-511, IL-1 beta +3954, IL-6-174, TNF-alpha-308, IL-10-1082, and IL-10-592 using Sequenome mass spectrometry-based genotyping technology. Toxicity was graded by the National Cancer Institute Common Toxicity Criteria version 2.0. Response was assessed by the Response Evaluation Criteria in Solid Tumors. Glasgow Prognostic Score, carcinoembryonic antigen and hypoalbuminemia were predictive of overall survival (OS). Hypoalbuminemia (
Original languageEnglish
Pages (from-to)331-337
JournalClinical Colorectal Cancer
Volume7
Issue number5
DOIs
Publication statusPublished - 2008

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