TY - JOUR
T1 - Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer
AU - Sharma, R.
AU - Zucknick, M.
AU - London, Roslyn
AU - Kacevska, M.
AU - Liddle, C.
AU - Clarke, S.J.
PY - 2008
Y1 - 2008
N2 - We aim to confirm the prognostic value of an inflammation-based prognostic score (the Glasgow Prognostic Score [GPS]) in advanced colorectal cancer,to explore a predictive pattern of plasma cytokines and their gene polymorphisms for clinical outcome, and to investigate which cytokines contribute to GPS. Inflammatory markers were measured at baseline in 52 patients with stage IV colorectal cancer. Germline DNA was genotyped for interleukin (IL)-1 beta-511, IL-1 beta +3954, IL-6-174, TNF-alpha-308, IL-10-1082, and IL-10-592 using Sequenome mass spectrometry-based genotyping technology. Toxicity was graded by the National Cancer Institute Common Toxicity Criteria version 2.0. Response was assessed by the Response Evaluation Criteria in Solid Tumors. Glasgow Prognostic Score, carcinoembryonic antigen and hypoalbuminemia were predictive of overall survival (OS). Hypoalbuminemia (
AB - We aim to confirm the prognostic value of an inflammation-based prognostic score (the Glasgow Prognostic Score [GPS]) in advanced colorectal cancer,to explore a predictive pattern of plasma cytokines and their gene polymorphisms for clinical outcome, and to investigate which cytokines contribute to GPS. Inflammatory markers were measured at baseline in 52 patients with stage IV colorectal cancer. Germline DNA was genotyped for interleukin (IL)-1 beta-511, IL-1 beta +3954, IL-6-174, TNF-alpha-308, IL-10-1082, and IL-10-592 using Sequenome mass spectrometry-based genotyping technology. Toxicity was graded by the National Cancer Institute Common Toxicity Criteria version 2.0. Response was assessed by the Response Evaluation Criteria in Solid Tumors. Glasgow Prognostic Score, carcinoembryonic antigen and hypoalbuminemia were predictive of overall survival (OS). Hypoalbuminemia (
U2 - 10.3816/CCC.2008.n.044
DO - 10.3816/CCC.2008.n.044
M3 - Article
VL - 7
SP - 331
EP - 337
JO - Clinical Colorectal Cancer
JF - Clinical Colorectal Cancer
SN - 1938-0674
IS - 5
ER -
