Patients with orofacial neuropathic pain typically present with symptoms first hand to their general dental practitioner. It is important dental practitioners recognise the clinical presentations of these conditions for prompt diagnosis and appropriate management. This review will focus on the systemic causes of orofacial neuropathy. Infectious and autoimmune diseases with orofacial neuropathic manifestations such as post-herpetic neuralgia, paroxysmal neuralgias, painful trigeminal sensory neuropathies, peripheral neuritis and oral dysaesthesia will be discussed. Specifically, the prevalence, pathophysiology, clinical presentations and management of these conditions will be reviewed.