Traditional soil stabilization by chemical additives such as cement and lime is a well-established technique for ground improvement of problematic soils. However, with the advantage of lower carbon emission and energy consumption, fly-ashbased geopolymer has recently become an attractive alternative to traditional stabilizers. Nevertheless, the literature lacks systemic approaches that assist engineers to apply this promising binder for soil stabilization, including the proper dosages required for an effective treatment. This paper introduces a systematic approach to assess the applicability of fly-ash-based geopolymer for stabilization of clay soils, through a comprehensive experimental program where engineered and natural clays were examined and evaluated, including soil compaction, plasticity, compressive strength, durability, pH level, and impact of pulverization. The results revealed several factors that influence the level of enhancement of geopolymer-treated clays, including the soil mineralogy, plasticity–activity properties, geopolymer concentration, curing time, and pulverization.