Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors

Travis Coyle, Liang Wu, Aleksandra W. Debowski, Gideon J. Davies, Keith A. Stubbs

Research output: Contribution to journalArticle

Abstract

The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α-l-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α-l-fucosidase inhibitors, with X-ray crystallographic analysis using an α-l-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class.

Original languageEnglish
Pages (from-to)1365-1368
Number of pages4
JournalChemBioChem
Volume20
Issue number11
DOIs
Publication statusPublished - 3 Jun 2019

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