Synthesizing cellular networks from evolved ribosome-mRNA pairs

O Rackham; Jason Chin

doi:10.1042/BST20060328

Synthesizing cellular networks from evolved ribosome-mRNA pairs

O Rackham, Jason Chin

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We describe cellular engineering for the creation of multiple new cellular modules each composed of an orthogonal ribosome and orthogonal mRNA. These modules operate independently of the endogenous ribosome and mRNA. We discuss some of the applications of orthogonal pairs and highlight the expression of Boolean logic in gene regulation using multiple orthogonal pairs.

Original language	English
Pages (from-to)	328-9
Number of pages	2
Journal	Biochemical Society Transactions
Volume	34
Issue number	Pt 2
DOIs	https://doi.org/10.1042/BST20060328
Publication status	Published - Apr 2006
Externally published	Yes

Access to Document

10.1042/BST20060328

Cite this

@article{e534c748a184443f8afd0ddc8ae78067,

title = "Synthesizing cellular networks from evolved ribosome-mRNA pairs",

abstract = "We describe cellular engineering for the creation of multiple new cellular modules each composed of an orthogonal ribosome and orthogonal mRNA. These modules operate independently of the endogenous ribosome and mRNA. We discuss some of the applications of orthogonal pairs and highlight the expression of Boolean logic in gene regulation using multiple orthogonal pairs.",

keywords = "Biological Evolution, Gene Expression Regulation, Protein Binding, Protein Biosynthesis, RNA, Messenger/chemistry, Ribosomes/chemistry",

author = "O Rackham and Jason Chin",

year = "2006",

month = apr,

doi = "10.1042/BST20060328",

language = "English",

volume = "34",

pages = "328--9",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press Ltd.",

number = "Pt 2",

}

TY - JOUR

T1 - Synthesizing cellular networks from evolved ribosome-mRNA pairs

AU - Rackham, O

AU - Chin, Jason

PY - 2006/4

Y1 - 2006/4

N2 - We describe cellular engineering for the creation of multiple new cellular modules each composed of an orthogonal ribosome and orthogonal mRNA. These modules operate independently of the endogenous ribosome and mRNA. We discuss some of the applications of orthogonal pairs and highlight the expression of Boolean logic in gene regulation using multiple orthogonal pairs.

AB - We describe cellular engineering for the creation of multiple new cellular modules each composed of an orthogonal ribosome and orthogonal mRNA. These modules operate independently of the endogenous ribosome and mRNA. We discuss some of the applications of orthogonal pairs and highlight the expression of Boolean logic in gene regulation using multiple orthogonal pairs.

KW - Biological Evolution

KW - Gene Expression Regulation

KW - Protein Binding

KW - Protein Biosynthesis

KW - RNA, Messenger/chemistry

KW - Ribosomes/chemistry

UR - https://www.scopus.com/pages/publications/33645967779

U2 - 10.1042/BST20060328

DO - 10.1042/BST20060328

M3 - Article

C2 - 16545106

SN - 0300-5127

VL - 34

SP - 328

EP - 329

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - Pt 2

ER -

Synthesizing cellular networks from evolved ribosome-mRNA pairs

Abstract

Access to Document

Other files and links

Fingerprint

Cite this