Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole

A. R. Jalilian, P. Rowshanfarzad, H. Afarideh, A. Shafiee, M. Sabet, M. Kyoumarsi, Gh R. Raisali

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6 Citations (Scopus)

Abstract

Selenium-75 (t1/2=120.4d; 100% EC) was prepared in no-carrier-added form by 22MeV proton-bombardment of natural arsenic(III) oxide powder held in a copper-aluminum drawer target (highest yield, 35μCi/μAh; maximum current, 6μA), followed by oxidation to [75Se]selenium(IV) oxide. No-carrier-added [75Se]5-ethoxycarbonyl-4-methyl-1,2,3- selenadiazole was prepared in one step from ethylacetoacetate semicarbazone with [75Se]selenium(IV) oxide in glacial acetic acid at 50°C. Column chromatography of the final solution afforded the desired labeled compound in 30% yield and greater than 98% radiochemical purity.

Original languageEnglish
Pages (from-to)659-663
Number of pages5
JournalApplied Radiation and Isotopes
Volume60
Issue number5
DOIs
Publication statusPublished - 1 May 2004

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