TY - JOUR
T1 - Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole
AU - Jalilian, A. R.
AU - Rowshanfarzad, P.
AU - Afarideh, H.
AU - Shafiee, A.
AU - Sabet, M.
AU - Kyoumarsi, M.
AU - Raisali, Gh R.
PY - 2004/5/1
Y1 - 2004/5/1
N2 - Selenium-75 (t1/2=120.4d; 100% EC) was prepared in no-carrier-added form by 22MeV proton-bombardment of natural arsenic(III) oxide powder held in a copper-aluminum drawer target (highest yield, 35μCi/μAh; maximum current, 6μA), followed by oxidation to [75Se]selenium(IV) oxide. No-carrier-added [75Se]5-ethoxycarbonyl-4-methyl-1,2,3- selenadiazole was prepared in one step from ethylacetoacetate semicarbazone with [75Se]selenium(IV) oxide in glacial acetic acid at 50°C. Column chromatography of the final solution afforded the desired labeled compound in 30% yield and greater than 98% radiochemical purity.
AB - Selenium-75 (t1/2=120.4d; 100% EC) was prepared in no-carrier-added form by 22MeV proton-bombardment of natural arsenic(III) oxide powder held in a copper-aluminum drawer target (highest yield, 35μCi/μAh; maximum current, 6μA), followed by oxidation to [75Se]selenium(IV) oxide. No-carrier-added [75Se]5-ethoxycarbonyl-4-methyl-1,2,3- selenadiazole was prepared in one step from ethylacetoacetate semicarbazone with [75Se]selenium(IV) oxide in glacial acetic acid at 50°C. Column chromatography of the final solution afforded the desired labeled compound in 30% yield and greater than 98% radiochemical purity.
KW - 1,2,3-Selenadiazoles
KW - Drawer targets
KW - Se-75
UR - http://www.scopus.com/inward/record.url?scp=1842688017&partnerID=8YFLogxK
U2 - 10.1016/j.apradiso.2003.11.091
DO - 10.1016/j.apradiso.2003.11.091
M3 - Article
C2 - 15082043
AN - SCOPUS:1842688017
SN - 0969-8043
VL - 60
SP - 659
EP - 663
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
IS - 5
ER -