Synthesis of mono and bis[60]fullerene-based dicationic peptoids

S. Jennepalli, Kate Hammer, Thomas Riley, S.G. Pyne, P.A. Keller

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    © 2014 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Increasing numbers of biological applications of fullerenyl amino acids and their derivatives encouraged us to synthesise [60]fullerenyldihydropyrrole peptides, prepared from the coupling of mono- and bis[60]fullerenyldihydropyrrolecarboxylic acids 4, 5 and 41 with presynthesised peptides 13, 16, 24, 28, 29 and 46. The resulting hydrophobic scaffolded di- and tetra-cationic derivatives were tested against Staphylococcus aureus NCTC 6571 and Escherichia coli NCTC 10418. The synthesis, characterisation and biological results are discussed in this paper.
    Original languageEnglish
    Pages (from-to)195-201
    JournalEuropean Journal of Organic Chemistry
    Volume2015
    Issue number1
    DOIs
    Publication statusPublished - Jan 2015

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