© 2014 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Increasing numbers of biological applications of fullerenyl amino acids and their derivatives encouraged us to synthesise fullerenyldihydropyrrole peptides, prepared from the coupling of mono- and bisfullerenyldihydropyrrolecarboxylic acids 4, 5 and 41 with presynthesised peptides 13, 16, 24, 28, 29 and 46. The resulting hydrophobic scaffolded di- and tetra-cationic derivatives were tested against Staphylococcus aureus NCTC 6571 and Escherichia coli NCTC 10418. The synthesis, characterisation and biological results are discussed in this paper.
Jennepalli, S., Hammer, K., Riley, T., Pyne, S. G., & Keller, P. A. (2015). Synthesis of mono and bisfullerene-based dicationic peptoids. European Journal of Organic Chemistry, 2015(1), 195-201. https://doi.org/10.1002/ejoc.201403046