TY - JOUR
T1 - Synthesis of mono and bis[60]fullerene-based dicationic peptoids
AU - Jennepalli, S.
AU - Hammer, Kate
AU - Riley, Thomas
AU - Pyne, S.G.
AU - Keller, P.A.
PY - 2015/1
Y1 - 2015/1
N2 - © 2014 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Increasing numbers of biological applications of fullerenyl amino acids and their derivatives encouraged us to synthesise [60]fullerenyldihydropyrrole peptides, prepared from the coupling of mono- and bis[60]fullerenyldihydropyrrolecarboxylic acids 4, 5 and 41 with presynthesised peptides 13, 16, 24, 28, 29 and 46. The resulting hydrophobic scaffolded di- and tetra-cationic derivatives were tested against Staphylococcus aureus NCTC 6571 and Escherichia coli NCTC 10418. The synthesis, characterisation and biological results are discussed in this paper.
AB - © 2014 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Increasing numbers of biological applications of fullerenyl amino acids and their derivatives encouraged us to synthesise [60]fullerenyldihydropyrrole peptides, prepared from the coupling of mono- and bis[60]fullerenyldihydropyrrolecarboxylic acids 4, 5 and 41 with presynthesised peptides 13, 16, 24, 28, 29 and 46. The resulting hydrophobic scaffolded di- and tetra-cationic derivatives were tested against Staphylococcus aureus NCTC 6571 and Escherichia coli NCTC 10418. The synthesis, characterisation and biological results are discussed in this paper.
U2 - 10.1002/ejoc.201403046
DO - 10.1002/ejoc.201403046
M3 - Article
VL - 2015
SP - 195
EP - 201
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
SN - 1099-0690
IS - 1
ER -