Synthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy

Yanming Wang, Xin Ji, Peng Pang, Yunfeng Shi, Jian Dai, Jiake Xu, Jianping Wu, Thomas Brett Kirk, Wei Xue

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Chemo-photothermal therapy has attracted tremendous attention due to its synergistic effect in killing cancer cells, making it one of the most efficient therapies. Although most of the applied core-shell hybrid nanoparticles (NPs) can perform such a function, the lowering of their thermal efficiency through polymer coating and limited drug loading capacity severely limit their performance. Janus NPs with exposed metal and a polymer/silica matrix show improved chemo-and photothermal-efficiency, but have a complicated synthesis, and their loading capacity for hydrophobic drugs still needs to be optimized. Herein, we report the facile synthesis of Janus NPs comprising Au nanorods (NRs) and a hydrophobic polydivinylbenzene (PDVB) matrix. The UV-vis extinction of the Janus NPs is in the near infrared region (the region used in medicine), which makes it an ideal candidate for photothermal therapy, and the hydrophobic PDVB component is a good anticancer drug (curcumin) carrier for chemotherapy. With this combination of chemo-and photothermal-effects, a significant decrease in cell viability, migration, and invasion was realised, making the material a promising biomedical candidate for the treatment of cancer.

Original languageEnglish
Pages (from-to)2481-2488
Number of pages8
JournalJournal of Materials Chemistry B
Volume6
Issue number16
DOIs
Publication statusPublished - 28 Apr 2018

Cite this

Wang, Yanming ; Ji, Xin ; Pang, Peng ; Shi, Yunfeng ; Dai, Jian ; Xu, Jiake ; Wu, Jianping ; Kirk, Thomas Brett ; Xue, Wei. / Synthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy. In: Journal of Materials Chemistry B. 2018 ; Vol. 6, No. 16. pp. 2481-2488.
@article{9b3a26d02530432f9210961ecb59680b,
title = "Synthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy",
abstract = "Chemo-photothermal therapy has attracted tremendous attention due to its synergistic effect in killing cancer cells, making it one of the most efficient therapies. Although most of the applied core-shell hybrid nanoparticles (NPs) can perform such a function, the lowering of their thermal efficiency through polymer coating and limited drug loading capacity severely limit their performance. Janus NPs with exposed metal and a polymer/silica matrix show improved chemo-and photothermal-efficiency, but have a complicated synthesis, and their loading capacity for hydrophobic drugs still needs to be optimized. Herein, we report the facile synthesis of Janus NPs comprising Au nanorods (NRs) and a hydrophobic polydivinylbenzene (PDVB) matrix. The UV-vis extinction of the Janus NPs is in the near infrared region (the region used in medicine), which makes it an ideal candidate for photothermal therapy, and the hydrophobic PDVB component is a good anticancer drug (curcumin) carrier for chemotherapy. With this combination of chemo-and photothermal-effects, a significant decrease in cell viability, migration, and invasion was realised, making the material a promising biomedical candidate for the treatment of cancer.",
keywords = "GOLD-NANORODS, CANCER-TREATMENT, DRUG-DELIVERY, LIGHT, RELEASE, CELLS, DOXORUBICIN, RADIATION, CURCUMIN",
author = "Yanming Wang and Xin Ji and Peng Pang and Yunfeng Shi and Jian Dai and Jiake Xu and Jianping Wu and Kirk, {Thomas Brett} and Wei Xue",
year = "2018",
month = "4",
day = "28",
doi = "10.1039/c8tb00233a",
language = "English",
volume = "6",
pages = "2481--2488",
journal = "Journal of Materials Chemistry B",
issn = "2050-750X",
publisher = "ROYAL SOC CHEMISTRY",
number = "16",

}

Synthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy. / Wang, Yanming; Ji, Xin; Pang, Peng; Shi, Yunfeng; Dai, Jian; Xu, Jiake; Wu, Jianping; Kirk, Thomas Brett; Xue, Wei.

In: Journal of Materials Chemistry B, Vol. 6, No. 16, 28.04.2018, p. 2481-2488.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy

AU - Wang, Yanming

AU - Ji, Xin

AU - Pang, Peng

AU - Shi, Yunfeng

AU - Dai, Jian

AU - Xu, Jiake

AU - Wu, Jianping

AU - Kirk, Thomas Brett

AU - Xue, Wei

PY - 2018/4/28

Y1 - 2018/4/28

N2 - Chemo-photothermal therapy has attracted tremendous attention due to its synergistic effect in killing cancer cells, making it one of the most efficient therapies. Although most of the applied core-shell hybrid nanoparticles (NPs) can perform such a function, the lowering of their thermal efficiency through polymer coating and limited drug loading capacity severely limit their performance. Janus NPs with exposed metal and a polymer/silica matrix show improved chemo-and photothermal-efficiency, but have a complicated synthesis, and their loading capacity for hydrophobic drugs still needs to be optimized. Herein, we report the facile synthesis of Janus NPs comprising Au nanorods (NRs) and a hydrophobic polydivinylbenzene (PDVB) matrix. The UV-vis extinction of the Janus NPs is in the near infrared region (the region used in medicine), which makes it an ideal candidate for photothermal therapy, and the hydrophobic PDVB component is a good anticancer drug (curcumin) carrier for chemotherapy. With this combination of chemo-and photothermal-effects, a significant decrease in cell viability, migration, and invasion was realised, making the material a promising biomedical candidate for the treatment of cancer.

AB - Chemo-photothermal therapy has attracted tremendous attention due to its synergistic effect in killing cancer cells, making it one of the most efficient therapies. Although most of the applied core-shell hybrid nanoparticles (NPs) can perform such a function, the lowering of their thermal efficiency through polymer coating and limited drug loading capacity severely limit their performance. Janus NPs with exposed metal and a polymer/silica matrix show improved chemo-and photothermal-efficiency, but have a complicated synthesis, and their loading capacity for hydrophobic drugs still needs to be optimized. Herein, we report the facile synthesis of Janus NPs comprising Au nanorods (NRs) and a hydrophobic polydivinylbenzene (PDVB) matrix. The UV-vis extinction of the Janus NPs is in the near infrared region (the region used in medicine), which makes it an ideal candidate for photothermal therapy, and the hydrophobic PDVB component is a good anticancer drug (curcumin) carrier for chemotherapy. With this combination of chemo-and photothermal-effects, a significant decrease in cell viability, migration, and invasion was realised, making the material a promising biomedical candidate for the treatment of cancer.

KW - GOLD-NANORODS

KW - CANCER-TREATMENT

KW - DRUG-DELIVERY

KW - LIGHT

KW - RELEASE

KW - CELLS

KW - DOXORUBICIN

KW - RADIATION

KW - CURCUMIN

U2 - 10.1039/c8tb00233a

DO - 10.1039/c8tb00233a

M3 - Article

VL - 6

SP - 2481

EP - 2488

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-750X

IS - 16

ER -