Synthesis of Enantiopure C3-Symmetric Triangular Molecules

Tomoya Miura, Takayuki Nakamuro, Scott G. Stewart, Yuuya Nagata, Masahiro Murakami

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

An asymmetric synthesis of C3-symmetric triangular macrocycles is reported. 1-Methylsulfonyl-4-(4-vinylphenyl)-1,2,3-triazole undergoes a rhodium(II)-catalyzed cyclotrimerization to establish an enantiopure C3-symmetric triangular macrocycle motif. This method can be applied to the synthesis of an enantiopure hydrocarbon, which owes its chirality to asymmetric distribution of H/D atoms on the benzene rings.

Original languageEnglish
Pages (from-to)3334-3338
JournalAngewandte Chemie - International Edition
Volume56
Issue number12
DOIs
Publication statusPublished - 2017

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