TY - JOUR
T1 - Synthesis of 4-(1H-benzo[d]imidazol-2-yl) aniline derivatives of expected anti-HCV activity
AU - Khattab, Muhammad
AU - Ragab, FAF.
AU - Galal, SA.
AU - Diwani, HI. El
PY - 2012
Y1 - 2012
N2 - Starting from 4-(1H-benzo[d]imidazol-2-yl)aniline (1), derivatives of expected anti-HCV activity were prepared. Reaction of compound 1 with maleic anhydride yielded the α,β-unsaturated carboxylic acid 2 which was cyclized using hydrazine hydrate, phenylhydrazine or 4nitrophenylhydrazine to give the pyrazole derivatives 3, 4 & 5 respectively. Condensation of compound 1 with the pyrazolecarbaldehydes 6, 7, 8 & 9 afforded the corresponding schiff’s bases 11, 12, 13 & 14 respectively. The structures of the new compounds were confirmed by their spectral data and microanalyses.
AB - Starting from 4-(1H-benzo[d]imidazol-2-yl)aniline (1), derivatives of expected anti-HCV activity were prepared. Reaction of compound 1 with maleic anhydride yielded the α,β-unsaturated carboxylic acid 2 which was cyclized using hydrazine hydrate, phenylhydrazine or 4nitrophenylhydrazine to give the pyrazole derivatives 3, 4 & 5 respectively. Condensation of compound 1 with the pyrazolecarbaldehydes 6, 7, 8 & 9 afforded the corresponding schiff’s bases 11, 12, 13 & 14 respectively. The structures of the new compounds were confirmed by their spectral data and microanalyses.
UR - http://www.ijrpc.com/files/06-2160.pdf
M3 - Article
JO - International Journal of Research in Pharmacy and Chemistry
JF - International Journal of Research in Pharmacy and Chemistry
ER -