Synthesis of 4-(1H-benzo[d]imidazol-2-yl) aniline derivatives of expected anti-HCV activity

Muhammad Khattab, FAF. Ragab, SA. Galal, HI. El Diwani

Research output: Contribution to journalArticlepeer-review

Abstract

Starting from 4-(1H-benzo[d]imidazol-2-yl)aniline (1), derivatives of expected anti-HCV activity were prepared. Reaction of compound 1 with maleic anhydride yielded the α,β-unsaturated carboxylic acid 2 which was cyclized using hydrazine hydrate, phenylhydrazine or 4nitrophenylhydrazine to give the pyrazole derivatives 3, 4 & 5 respectively. Condensation of compound 1 with the pyrazolecarbaldehydes 6, 7, 8 & 9 afforded the corresponding schiff’s bases 11, 12, 13 & 14 respectively. The structures of the new compounds were confirmed by their spectral data and microanalyses.
Original languageEnglish
JournalInternational Journal of Research in Pharmacy and Chemistry
Publication statusPublished - 2012
Externally publishedYes

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