Synthesis of 1,3,4-Oxadiazoles via Annulation of Hydrazides and Benzene-1,3,5-triyl Triformate under Metal-Free Conditions

Z. Yin; D. J. Power; Z. Wang; S.G. Stewart; X.F. Wu

doi:10.1055/s-0037-1609481

Synthesis of 1,3,4-Oxadiazoles via Annulation of Hydrazides and Benzene-1,3,5-triyl Triformate under Metal-Free Conditions

Z. Yin, D. J. Power, Z. Wang, S.G. Stewart, X.F. Wu

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3,4-oxadiazoles in good yields with excellent functional group tolerance.

Original language	English
Pages (from-to)	3238-3242
Number of pages	5
Journal	Synthesis (Germany)
Volume	50
Issue number	16
DOIs	https://doi.org/10.1055/s-0037-1609481
Publication status	Published - 16 Apr 2018

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abstract = "A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3,4-oxadiazoles in good yields with excellent functional group tolerance.",

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author = "Z. Yin and Power, {D. J.} and Z. Wang and S.G. Stewart and X.F. Wu",

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AU - Yin, Z.

AU - Power, D. J.

AU - Wang, Z.

AU - Stewart, S.G.

AU - Wu, X.F.

PY - 2018/4/16

Y1 - 2018/4/16

N2 - A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3,4-oxadiazoles in good yields with excellent functional group tolerance.

AB - A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3,4-oxadiazoles in good yields with excellent functional group tolerance.

KW - carbonylation

KW - cyclisation

KW - formates

KW - green chemistry

KW - heterocycles

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U2 - 10.1055/s-0037-1609481

DO - 10.1055/s-0037-1609481

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JF - Synthesis

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ER -

Synthesis of 1,3,4-Oxadiazoles via Annulation of Hydrazides and Benzene-1,3,5-triyl Triformate under Metal-Free Conditions

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