Synthesis, Characterization, and Bioactivity of the Lichen Pigments Pulvinamide, Rhizocarpic Acid, and Epanorin and Congeners

Patrick J.C. James, Daniel Vuong, Stephen A. Moggach, Ernest Lacey, Matthew J. Piggott

Research output: Contribution to journalArticlepeer-review

Abstract

The lichen natural products pulvinamide, rhizocarpic acid, and epanorin have been synthesized and characterized spectroscopically and by X-ray crystallography. The syntheses, by ring-opening of pulvinic acid dilactone (PAD), may well be biomimetic, given the well-known occurrence of PAD in lichen. The enantiomers, ent-rhizocarpic acid and ent-epanorin, and corresponding carboxylic acids, norrhizocarpic acid and norepanorin, were similarly prepared. All compounds were assessed for growth inhibitory activity against selected bacteria, fungi, a protist, a mammalian tumor cell line, and normal cells. Rhizocarpic acid is weakly antibacterial (Bacillus subtilis MIC = 50 μg/mL) and possesses modest but selective antitumor activity (NS-1 murine myeloma MIC = 3.1 μg/mL) with >10-fold potency relative to its enantiomer (MIC = 50 μg/mL).
Original languageEnglish
Pages (from-to)550-556
Number of pages7
JournalJournal of Natural Products
Volume86
Issue number3
DOIs
Publication statusPublished - 24 Mar 2023

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