Synthesis, anti-cancer, and antimicrobial studies of gold(l) complexes with N-Heterocyclic carbenes and carbohydrate-based ligands

Weihao Zhao

doi:10.26182/0xww-ja32

Synthesis, anti-cancer, and antimicrobial studies of gold(l) complexes with N-Heterocyclic carbenes and carbohydrate-based ligands

Weihao Zhao

School of Molecular Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

This thesis focuses on synthesis and biological investigation of new gold(I)-NHC complexes (NHC = N-heterocyclic carbene) .The new complexes include analogs of well-known gold(I) drug auranofin of form (NHC)AuX, built from a range of imidazolium salts that have a pendant acetyl-protected carbohydrate group. The synthesis and characterization of these complexes were discussed in detail. Anti-cancer activity of these gold complexes was extensively investigated via Cellavista essays and CyTOF techniques, using tumorogenic and non-tumorogenic liver (BMOL) cell lines. Anti-microbial activity of the new complexes was also briefly studied and discussed.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Baker, Murray, Supervisor Dorta, Reto, Supervisor
Award date	11 Jun 2024
DOIs	https://doi.org/10.26182/0xww-ja32
Publication status	Unpublished - 2019

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THESIS - DOCTOR OF PHILOSOPHY - ZHAO Weihao - 2019
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title = "Synthesis, anti-cancer, and antimicrobial studies of gold(l) complexes with N-Heterocyclic carbenes and carbohydrate-based ligands",

abstract = "This thesis focuses on synthesis and biological investigation of new gold(I)-NHC complexes (NHC = N-heterocyclic carbene) .The new complexes include analogs of well-known gold(I) drug auranofin of form (NHC)AuX, built from a range of imidazolium salts that have a pendant acetyl-protected carbohydrate group. The synthesis and characterization of these complexes were discussed in detail. Anti-cancer activity of these gold complexes was extensively investigated via Cellavista essays and CyTOF techniques, using tumorogenic and non-tumorogenic liver (BMOL) cell lines. Anti-microbial activity of the new complexes was also briefly studied and discussed.",

keywords = "Organometallics, Anticancer, Carbohydrates, Gold complexes",

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year = "2019",

doi = "10.26182/0xww-ja32",

language = "English",

school = "The University of Western Australia",

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AU - Zhao, Weihao

PY - 2019

Y1 - 2019

N2 - This thesis focuses on synthesis and biological investigation of new gold(I)-NHC complexes (NHC = N-heterocyclic carbene) .The new complexes include analogs of well-known gold(I) drug auranofin of form (NHC)AuX, built from a range of imidazolium salts that have a pendant acetyl-protected carbohydrate group. The synthesis and characterization of these complexes were discussed in detail. Anti-cancer activity of these gold complexes was extensively investigated via Cellavista essays and CyTOF techniques, using tumorogenic and non-tumorogenic liver (BMOL) cell lines. Anti-microbial activity of the new complexes was also briefly studied and discussed.

AB - This thesis focuses on synthesis and biological investigation of new gold(I)-NHC complexes (NHC = N-heterocyclic carbene) .The new complexes include analogs of well-known gold(I) drug auranofin of form (NHC)AuX, built from a range of imidazolium salts that have a pendant acetyl-protected carbohydrate group. The synthesis and characterization of these complexes were discussed in detail. Anti-cancer activity of these gold complexes was extensively investigated via Cellavista essays and CyTOF techniques, using tumorogenic and non-tumorogenic liver (BMOL) cell lines. Anti-microbial activity of the new complexes was also briefly studied and discussed.

KW - Organometallics

KW - Anticancer

KW - Carbohydrates

KW - Gold complexes

U2 - 10.26182/0xww-ja32

DO - 10.26182/0xww-ja32

M3 - Doctoral Thesis

ER -

Synthesis, anti-cancer, and antimicrobial studies of gold(l) complexes with N-Heterocyclic carbenes and carbohydrate-based ligands

Abstract

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