N-Methylation of 6,7-dimethoxy-1-(2'-phenylcyclopropyl)-3,4-dihydroisoquinoline (3b) with iodomethane in refluxing acetone gave the modified Cloke rearrangement product, 8,9-dimethoxy-4-methyl-3-phenyl-2,3,5,6-tetrahyropyrrolo [2,1-a]isoquinolinium iodide (5b), a new derivative of the pyrrolo[2,1-a]isoquinoline skeleton, together with the methiodide salt (4b) of (3b). The structure of (5b) was confirmed by X-ray crystallographic analysis.
|Journal||Australian Journal of Chemistry: an international journal for chemical science|
|Publication status||Published - 1995|
Bailey, T. S., Bremner, J. B., Pelosi, L., Skelton, B., & White, A. (1995). Synthesis and X-ray crystal structure of 8,9-dimethoxy-4-methyl-3-phenyl-2,3,5,6-tetrahydropyrrolo[2,1-a]isoquinolinium iodide. Australian Journal of Chemistry: an international journal for chemical science, 48, 1437-1445. https://doi.org/10.1071/CH9951437