Syntheses and biological investigations of kirkamide and oseltamivir hybrid derivatives

Simon Sieber, Chien Chi Hsiao, Despina Emmanouilidou, Aleksandra W. Debowski, Keith A. Stubbs, Karl Gademann

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The C7N-aminocyclitol kirkamide was recently isolated from the plant obligate symbiont Candidatus Burkholderia kirkii and was hypothesized to be beneficial to the plant host due to its cytotoxic activity against insects and arthropods. To study its mechanism of action and inspired by its structural similarity with N-acetylglucosamine (GlcNAc) and oseltamivir, kirkamide-oseltamivir hybrid derivatives were synthesized and investigated for their biological activity. Interestingly, kirkamide analogues were reasonably potent against a known bacterial neuraminidase.

Original languageEnglish
Article number131386
Issue number51
Early online date14 Jul 2020
Publication statusPublished - 18 Dec 2020


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