Syndromic gastric polyposis and hereditary gastric cancers

Till S. Clauditz, Michelle Moore, Namrata Setia, M. P. Kumarasinghe, Gregory Y. Lauwers

Research output: Contribution to journalArticlepeer-review


Although the majority of gastric carcinomas are sporadic neoplasms, approximately 10% show familial aggregation, and a hereditary cause is determined in 1–3% cases. Of these, hereditary diffuse gastric cancer (HDGC) is the most recognized predisposition syndrome. Although rare, some of the less commonly reported syndromes (including polyposis syndrome), also confer a markedly increased risk for development of gastric cancer. Identification and characterization of these syndromes requires a multidisciplinary effort involving oncologists, surgeons, genetic counselors, and pathologists.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalDiagnostic Histopathology
Issue number1
Publication statusPublished - Jan 2020


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