TY - JOUR
T1 - Syndromic gastric polyposis and hereditary gastric cancers
AU - Clauditz, Till S.
AU - Moore, Michelle
AU - Setia, Namrata
AU - Kumarasinghe, M. P.
AU - Lauwers, Gregory Y.
PY - 2020/1
Y1 - 2020/1
N2 - Although the majority of gastric carcinomas are sporadic neoplasms, approximately 10% show familial aggregation, and a hereditary cause is determined in 1–3% cases. Of these, hereditary diffuse gastric cancer (HDGC) is the most recognized predisposition syndrome. Although rare, some of the less commonly reported syndromes (including polyposis syndrome), also confer a markedly increased risk for development of gastric cancer. Identification and characterization of these syndromes requires a multidisciplinary effort involving oncologists, surgeons, genetic counselors, and pathologists.
AB - Although the majority of gastric carcinomas are sporadic neoplasms, approximately 10% show familial aggregation, and a hereditary cause is determined in 1–3% cases. Of these, hereditary diffuse gastric cancer (HDGC) is the most recognized predisposition syndrome. Although rare, some of the less commonly reported syndromes (including polyposis syndrome), also confer a markedly increased risk for development of gastric cancer. Identification and characterization of these syndromes requires a multidisciplinary effort involving oncologists, surgeons, genetic counselors, and pathologists.
KW - gastric cancer syndromes
KW - gastric polyposis
KW - gastric polyps
UR - http://www.scopus.com/inward/record.url?scp=85076475814&partnerID=8YFLogxK
U2 - 10.1016/j.mpdhp.2019.10.013
DO - 10.1016/j.mpdhp.2019.10.013
M3 - Article
AN - SCOPUS:85076475814
VL - 26
SP - 39
EP - 46
JO - Diagnostic Histopathology
JF - Diagnostic Histopathology
SN - 1756-2317
IS - 1
ER -
