Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults

Elisabeth Lambert, Carolina Ika Sari, Tye Dawood, Julie Nguyen, Mariee McGrane, Nina Eikelis, Reena Chopra, Chiew Wong, Kanella Chatzivlastou, Geoff Head, Nora Straznicky, Murray Esler, Markus Schlaich, Gavin Lambert

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Excess weight is established as a major risk factor for cardiovascular diseases, particularly in young individuals. To get a better understanding of the pathophysiology underlying increased cardiovascular disease risk, we evaluated early signs of organ damage and their possible relationship to sympathetic nervous activity. Eighteen lean (body mass index <25 kg/m 2) and 25 overweight or obese (body mass index >25 kg/m 2) healthy university students were included in the study. We comprehensively assessed subclinical target organ damage, including the following: (1) assessment of renal function; (2) left ventricular structure and systolic and diastolic function; and (3) endothelial function. Muscle sympathetic nervous activity was assessed by microneurography. Participants with excess weight had decreased endothelial function (P<0.01), elevated creatinine clearance (P<0.05), increased left ventricular mass index (P<0.05), increased left ventricular wall thickness (P<0.01), lower systolic and diastolic function (P<0.01), and elevated muscle sympathetic nervous activity (P<0.001) compared with lean individuals. In multiple regression analysis, endothelial function was inversely related to muscle sympathetic nervous activity (R2=0.244; P<0.05), whereas creatinine clearance and left ventricular mass index were positively related to muscle sympathetic nervous activity, after adjustment for body mass index, sex, and blood pressure (R2=0.318, P<0.01 and R2=0.312, P<0.05, respectively). Excess weight in young individuals is associated with subclinical alterations in renal and endothelial function, as well as in the structure of the heart, even in the absence of hypertension. Sympathetic activity is closely associated with cardiovascular and renal alterations observed in these subjects.

Original languageEnglish
Pages (from-to)351-358
Number of pages8
JournalHypertension
Volume56
Issue number3
DOIs
Publication statusPublished - 1 Sep 2010
Externally publishedYes

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Sympathetic Nervous System
Young Adult
Obesity
Muscles
Kidney
Weights and Measures
Creatinine
Body Mass Index
Cardiovascular Diseases
Regression Analysis
Students
Blood Pressure
Hypertension

Cite this

Lambert, E., Sari, C. I., Dawood, T., Nguyen, J., McGrane, M., Eikelis, N., ... Lambert, G. (2010). Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults. Hypertension, 56(3), 351-358. https://doi.org/10.1161/HYPERTENSIONAHA.110.155663
Lambert, Elisabeth ; Sari, Carolina Ika ; Dawood, Tye ; Nguyen, Julie ; McGrane, Mariee ; Eikelis, Nina ; Chopra, Reena ; Wong, Chiew ; Chatzivlastou, Kanella ; Head, Geoff ; Straznicky, Nora ; Esler, Murray ; Schlaich, Markus ; Lambert, Gavin. / Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults. In: Hypertension. 2010 ; Vol. 56, No. 3. pp. 351-358.
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Lambert, E, Sari, CI, Dawood, T, Nguyen, J, McGrane, M, Eikelis, N, Chopra, R, Wong, C, Chatzivlastou, K, Head, G, Straznicky, N, Esler, M, Schlaich, M & Lambert, G 2010, 'Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults' Hypertension, vol. 56, no. 3, pp. 351-358. https://doi.org/10.1161/HYPERTENSIONAHA.110.155663

Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults. / Lambert, Elisabeth; Sari, Carolina Ika; Dawood, Tye; Nguyen, Julie; McGrane, Mariee; Eikelis, Nina; Chopra, Reena; Wong, Chiew; Chatzivlastou, Kanella; Head, Geoff; Straznicky, Nora; Esler, Murray; Schlaich, Markus; Lambert, Gavin.

In: Hypertension, Vol. 56, No. 3, 01.09.2010, p. 351-358.

Research output: Contribution to journalArticle

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AU - Sari, Carolina Ika

AU - Dawood, Tye

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AU - Eikelis, Nina

AU - Chopra, Reena

AU - Wong, Chiew

AU - Chatzivlastou, Kanella

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AU - Esler, Murray

AU - Schlaich, Markus

AU - Lambert, Gavin

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