SV channels dominate the vacuolar Ca2+ release during intracellular signaling

Igor Pottosin, Tim Wherrett, Sergey Shabala

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


Vacuoles have long been suggested to mediate a rise in the cytosolic free Ca2+ during environmental signal transduction. This study addresses the issue of the control of vacuolar calcium release by some of the known signaling molecules such as IP3, cADPR, ABA, ATP, cAMP, cGMP, H2O2 and CaM. Over 30 concentrations and/or combinations of these signaling compounds were studied in a series of electrophysiological experiments involving non-invasive ion flux measurements (the MIFE) and patch-clamp techniques. Our results suggest that calcium, calmodulin and nucleotides cause calcium release via SV channels.

Original languageEnglish
Pages (from-to)921-926
Number of pages6
JournalFEBS Letters
Issue number5
Publication statusPublished - 4 Mar 2009
Externally publishedYes


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