Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10

Samuel Halstrom; Rachel Thomson; Hayley Goullee; Svetlana Baltic; Richard Allcock; Suzanna E L Temple; Patricia Price

doi:10.1016/j.humimm.2017.02.001

Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10

Samuel Halstrom, Rachel Thomson, Hayley Goullee, Svetlana Baltic, Richard Allcock, Suzanna E L Temple, Patricia Price

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896.

Original language	English
Pages (from-to)	391-393
Number of pages	3
Journal	Human Immunology
Volume	78
Issue number	4
DOIs	https://doi.org/10.1016/j.humimm.2017.02.001
Publication status	Published - 1 Apr 2017

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10.1016/j.humimm.2017.02.001

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title = "Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10",

abstract = "Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896.",

keywords = "Genetic polymorphism, IL10, Nontuberculous mycobacteria, Pulmonary disease",

author = "Samuel Halstrom and Rachel Thomson and Hayley Goullee and Svetlana Baltic and Richard Allcock and Temple, {Suzanna E L} and Patricia Price",

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AU - Halstrom, Samuel

AU - Thomson, Rachel

AU - Goullee, Hayley

AU - Baltic, Svetlana

AU - Allcock, Richard

AU - Temple, Suzanna E L

AU - Price, Patricia

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896.

AB - Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896.

KW - Genetic polymorphism

KW - IL10

KW - Nontuberculous mycobacteria

KW - Pulmonary disease

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AN - SCOPUS:85013141400

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JO - Human Immunology

JF - Human Immunology

IS - 4

ER -

Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10

Abstract

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