Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10

Samuel Halstrom, Rachel Thomson, Hayley Goullee, Svetlana Baltic, Richard Allcock, Suzanna E L Temple, Patricia Price

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Abstract

Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896.

Original languageEnglish
Pages (from-to)391-393
Number of pages3
JournalHuman Immunology
Volume78
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017

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Halstrom, S., Thomson, R., Goullee, H., Baltic, S., Allcock, R., Temple, S. E. L., & Price, P. (2017). Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10. Human Immunology, 78(4), 391-393. https://doi.org/10.1016/j.humimm.2017.02.001