Survival protein A is essential for virulence in Yersinia pestis

S.J. Southern, A.E. Scott, D.C. Jenner, P.M. Ireland, I.H. Norville, Mitali Sarkar-Tyson

    Research output: Contribution to journalArticle

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    Abstract

    © 2016 . Plague is a highly pathogenic disease caused by the bacterium Yersinia pestis. There is currently no vaccine available for prophylaxis and antibiotic resistant strains have been isolated, thus there is a need for the development of new countermeasures to treat this disease. Survival protein A (SurA) is a chaperone that has been linked to virulence in several species of bacteria, including the close relative Yersinia pseudotuberculosis. In this study, we aimed to evaluate the role of SurA in virulence of the highly pathogenic Y. pestis by creating an unmarked surA deletion mutant. The Y. pestis δsurA mutant was found to be more susceptible to membrane perturbing agents and was completely avirulent in a mouse infection model when delivered up to 2.1 × 105 CFU by the subcutaneous route. This provides strong evidence that SurA would make a promising antimicrobial target.
    Original languageEnglish
    Pages (from-to)50-53
    JournalMicrobial Pathogenesis
    Volume92
    DOIs
    Publication statusPublished - 2016

    Fingerprint

    Yersinia pestis
    Staphylococcal Protein A
    Virulence
    Yersinia pseudotuberculosis
    Bacteria
    Plague
    Antibiotic Prophylaxis
    Vaccines
    Membranes
    Infection

    Cite this

    Southern, S. J., Scott, A. E., Jenner, D. C., Ireland, P. M., Norville, I. H., & Sarkar-Tyson, M. (2016). Survival protein A is essential for virulence in Yersinia pestis. Microbial Pathogenesis, 92, 50-53. https://doi.org/10.1016/j.micpath.2015.12.013
    Southern, S.J. ; Scott, A.E. ; Jenner, D.C. ; Ireland, P.M. ; Norville, I.H. ; Sarkar-Tyson, Mitali. / Survival protein A is essential for virulence in Yersinia pestis. In: Microbial Pathogenesis. 2016 ; Vol. 92. pp. 50-53.
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    Survival protein A is essential for virulence in Yersinia pestis. / Southern, S.J.; Scott, A.E.; Jenner, D.C.; Ireland, P.M.; Norville, I.H.; Sarkar-Tyson, Mitali.

    In: Microbial Pathogenesis, Vol. 92, 2016, p. 50-53.

    Research output: Contribution to journalArticle

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    AB - © 2016 . Plague is a highly pathogenic disease caused by the bacterium Yersinia pestis. There is currently no vaccine available for prophylaxis and antibiotic resistant strains have been isolated, thus there is a need for the development of new countermeasures to treat this disease. Survival protein A (SurA) is a chaperone that has been linked to virulence in several species of bacteria, including the close relative Yersinia pseudotuberculosis. In this study, we aimed to evaluate the role of SurA in virulence of the highly pathogenic Y. pestis by creating an unmarked surA deletion mutant. The Y. pestis δsurA mutant was found to be more susceptible to membrane perturbing agents and was completely avirulent in a mouse infection model when delivered up to 2.1 × 105 CFU by the subcutaneous route. This provides strong evidence that SurA would make a promising antimicrobial target.

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