TY - JOUR
T1 - Successful control of viruses by NK cells - a balance of opposing forces
AU - Scalzo, Tony
PY - 2002
Y1 - 2002
N2 - Natural killer (NK) cells play a crucial role in limiting the severity of diseases caused by a range of viruses. Recent data have shown that the effector functions of NK cells can be specifically stimulated when NK cell activation receptors engage cellular major histocompatibility complex (MHC) class I-like ligands induced after infection or by specific viral gene products. However, to counter this NK cell response viruses have evolved an array of strategies to subvert efficient NK cell activation. These data indicate that the balance of host NK cell responses and viral NK cell escape mechanisms can be strategically poised as each strives for survival.
AB - Natural killer (NK) cells play a crucial role in limiting the severity of diseases caused by a range of viruses. Recent data have shown that the effector functions of NK cells can be specifically stimulated when NK cell activation receptors engage cellular major histocompatibility complex (MHC) class I-like ligands induced after infection or by specific viral gene products. However, to counter this NK cell response viruses have evolved an array of strategies to subvert efficient NK cell activation. These data indicate that the balance of host NK cell responses and viral NK cell escape mechanisms can be strategically poised as each strives for survival.
UR - https://www.scopus.com/pages/publications/0036789819
U2 - 10.1016/S0966-842X(02)02441-1
DO - 10.1016/S0966-842X(02)02441-1
M3 - Article
SN - 0966-842X
VL - 10
SP - 470
EP - 474
JO - Trends in Microbiology
JF - Trends in Microbiology
ER -
