Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults

Louise N Pivac; Belinda M Brown; Kelsey R Sewell; James D Doecke; Victor L Villemagne; Vincent Doré; Michael Weinborn; Hamid R Sohrabi; Samantha L Gardener; Romola S Bucks; Simon M Laws; Kevin Taddei; Paul Maruff; Colin L Masters; Christopher Rowe; Ralph N Martins; Stephanie R Rainey-Smith

doi:10.1002/dad2.12579

Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults

Louise N Pivac, Belinda M Brown, Kelsey R Sewell, James D Doecke, Victor L Villemagne, Vincent Doré, Michael Weinborn, Hamid R Sohrabi, Samantha L Gardener, Romola S Bucks, Simon M Laws, Kevin Taddei, Paul Maruff, Colin L Masters, Christopher Rowe, Ralph N Martins, Stephanie R Rainey-Smith

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: This study investigated whether self-reported sleep quality is associated with brain amyloid beta (Aβ) accumulation.

METHODS: Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (mean ± standard deviation 74.0 ± 6.2; 53.2% female), with baseline self-reported sleep data, and positron emission tomography-determined brain Aβ measured over a minimum of three time points (range 33.3-72.7 months). Analyses included random slopes and intercepts, interaction for apolipoprotein E ( APOE) ε4 allele status, and time, adjusting for sex and baseline age.

RESULTS: Sleep duration <6 hours, in APOE ε4 carriers, and sleep efficiency <65%, in the whole sample and APOE ε4 non-carriers, is associated with faster accumulation of brain Aβ.

DISCUSSION: These findings suggest a role for self-reported suboptimal sleep efficiency and duration in the accumulation of Alzheimer's disease (AD) neuropathology in CU individuals. Additionally, poor sleep efficiency represents a potential route via which individuals at lower genetic risk may progress to preclinical AD.

HIGHLIGHTS: In cognitively unimpaired older adults self-report sleep is associated with brain amyloid beta (Aβ) accumulation.Across sleep characteristics, this relationship differs by apolipoprotein E ( APOE) genotype.Sleep duration <6 hours is associated with faster brain Aβ accumulation in APOE ε4 carriers.Sleep efficiency < 65% is associated with faster brain Aβ accumulation in APOE ε4 non-carriers.Personalized sleep interventions should be studied for potential to slow Aβ accumulation.

Original language	English
Article number	e12579
Number of pages	11
Journal	Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume	16
Issue number	2
DOIs	https://doi.org/10.1002/dad2.12579
Publication status	Published - 2024

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10.1002/dad2.12579Licence: CC BY

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Pivac, L. N., Brown, B. M., Sewell, K. R., Doecke, J. D., Villemagne, V. L., Doré, V., Weinborn, M., Sohrabi, H. R., Gardener, S. L., Bucks, R. S., Laws, S. M., Taddei, K., Maruff, P., Masters, C. L., Rowe, C., Martins, R. N., & Rainey-Smith, S. R. (2024). Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 16(2), Article e12579. https://doi.org/10.1002/dad2.12579

@article{8be2b72193944183ab9839b34f46c9ff,

title = "Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults",

abstract = "INTRODUCTION: This study investigated whether self-reported sleep quality is associated with brain amyloid beta (Aβ) accumulation.METHODS: Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (mean ± standard deviation 74.0 ± 6.2; 53.2% female), with baseline self-reported sleep data, and positron emission tomography-determined brain Aβ measured over a minimum of three time points (range 33.3-72.7 months). Analyses included random slopes and intercepts, interaction for apolipoprotein E ( APOE) ε4 allele status, and time, adjusting for sex and baseline age. RESULTS: Sleep duration <6 hours, in APOE ε4 carriers, and sleep efficiency <65%, in the whole sample and APOE ε4 non-carriers, is associated with faster accumulation of brain Aβ. DISCUSSION: These findings suggest a role for self-reported suboptimal sleep efficiency and duration in the accumulation of Alzheimer's disease (AD) neuropathology in CU individuals. Additionally, poor sleep efficiency represents a potential route via which individuals at lower genetic risk may progress to preclinical AD.HIGHLIGHTS: In cognitively unimpaired older adults self-report sleep is associated with brain amyloid beta (Aβ) accumulation.Across sleep characteristics, this relationship differs by apolipoprotein E ( APOE) genotype.Sleep duration <6 hours is associated with faster brain Aβ accumulation in APOE ε4 carriers.Sleep efficiency < 65% is associated with faster brain Aβ accumulation in APOE ε4 non-carriers.Personalized sleep interventions should be studied for potential to slow Aβ accumulation. ",

author = "Pivac, {Louise N} and Brown, {Belinda M} and Sewell, {Kelsey R} and Doecke, {James D} and Villemagne, {Victor L} and Vincent Dor{\'e} and Michael Weinborn and Sohrabi, {Hamid R} and Gardener, {Samantha L} and Bucks, {Romola S} and Laws, {Simon M} and Kevin Taddei and Paul Maruff and Masters, {Colin L} and Christopher Rowe and Martins, {Ralph N} and Rainey-Smith, {Stephanie R}",

note = "{\textcopyright} 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2024",

doi = "10.1002/dad2.12579",

language = "English",

volume = "16",

journal = "Alzheimer{\textquoteright}s & Dementia: Diagnosis, Assessment & Disease Monitoring",

issn = "2352-8729",

publisher = "Elsevier",

number = "2",

}

Pivac, LN, Brown, BM, Sewell, KR, Doecke, JD, Villemagne, VL, Doré, V, Weinborn, M, Sohrabi, HR, Gardener, SL, Bucks, RS, Laws, SM, Taddei, K, Maruff, P, Masters, CL, Rowe, C, Martins, RN & Rainey-Smith, SR 2024, 'Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults', Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 16, no. 2, e12579. https://doi.org/10.1002/dad2.12579

Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults. / Pivac, Louise N; Brown, Belinda M; Sewell, Kelsey R et al.
In: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 16, No. 2, e12579, 2024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults

AU - Pivac, Louise N

AU - Brown, Belinda M

AU - Sewell, Kelsey R

AU - Doecke, James D

AU - Villemagne, Victor L

AU - Doré, Vincent

AU - Weinborn, Michael

AU - Sohrabi, Hamid R

AU - Gardener, Samantha L

AU - Bucks, Romola S

AU - Laws, Simon M

AU - Taddei, Kevin

AU - Maruff, Paul

AU - Masters, Colin L

AU - Rowe, Christopher

AU - Martins, Ralph N

AU - Rainey-Smith, Stephanie R

PY - 2024

Y1 - 2024

N2 - INTRODUCTION: This study investigated whether self-reported sleep quality is associated with brain amyloid beta (Aβ) accumulation.METHODS: Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (mean ± standard deviation 74.0 ± 6.2; 53.2% female), with baseline self-reported sleep data, and positron emission tomography-determined brain Aβ measured over a minimum of three time points (range 33.3-72.7 months). Analyses included random slopes and intercepts, interaction for apolipoprotein E ( APOE) ε4 allele status, and time, adjusting for sex and baseline age. RESULTS: Sleep duration <6 hours, in APOE ε4 carriers, and sleep efficiency <65%, in the whole sample and APOE ε4 non-carriers, is associated with faster accumulation of brain Aβ. DISCUSSION: These findings suggest a role for self-reported suboptimal sleep efficiency and duration in the accumulation of Alzheimer's disease (AD) neuropathology in CU individuals. Additionally, poor sleep efficiency represents a potential route via which individuals at lower genetic risk may progress to preclinical AD.HIGHLIGHTS: In cognitively unimpaired older adults self-report sleep is associated with brain amyloid beta (Aβ) accumulation.Across sleep characteristics, this relationship differs by apolipoprotein E ( APOE) genotype.Sleep duration <6 hours is associated with faster brain Aβ accumulation in APOE ε4 carriers.Sleep efficiency < 65% is associated with faster brain Aβ accumulation in APOE ε4 non-carriers.Personalized sleep interventions should be studied for potential to slow Aβ accumulation.

AB - INTRODUCTION: This study investigated whether self-reported sleep quality is associated with brain amyloid beta (Aβ) accumulation.METHODS: Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (mean ± standard deviation 74.0 ± 6.2; 53.2% female), with baseline self-reported sleep data, and positron emission tomography-determined brain Aβ measured over a minimum of three time points (range 33.3-72.7 months). Analyses included random slopes and intercepts, interaction for apolipoprotein E ( APOE) ε4 allele status, and time, adjusting for sex and baseline age. RESULTS: Sleep duration <6 hours, in APOE ε4 carriers, and sleep efficiency <65%, in the whole sample and APOE ε4 non-carriers, is associated with faster accumulation of brain Aβ. DISCUSSION: These findings suggest a role for self-reported suboptimal sleep efficiency and duration in the accumulation of Alzheimer's disease (AD) neuropathology in CU individuals. Additionally, poor sleep efficiency represents a potential route via which individuals at lower genetic risk may progress to preclinical AD.HIGHLIGHTS: In cognitively unimpaired older adults self-report sleep is associated with brain amyloid beta (Aβ) accumulation.Across sleep characteristics, this relationship differs by apolipoprotein E ( APOE) genotype.Sleep duration <6 hours is associated with faster brain Aβ accumulation in APOE ε4 carriers.Sleep efficiency < 65% is associated with faster brain Aβ accumulation in APOE ε4 non-carriers.Personalized sleep interventions should be studied for potential to slow Aβ accumulation.

U2 - 10.1002/dad2.12579

DO - 10.1002/dad2.12579

M3 - Article

C2 - 38651160

SN - 2352-8729

VL - 16

JO - Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

JF - Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

IS - 2

M1 - e12579

ER -

Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults

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