Subjective memory complaints predict baseline but not future cognitive function over three years: Results from the Western Australia Memory Study

Hamid R. Sohrabi, Michael Weinborn, Christoph Laske, Kristyn A. Bates, Daniel Christensen, Kevin Taddei, Stephanie R. Rainey-Smith, Belinda M. Brown, Samantha L. Gardener, Simon M. Laws, Georgia Martins, Samantha C. Burnham, Romola S. Bucks, Barry Reisberg, Nicola T. Lautenschlager, Jonathan Foster, Ralph N. Martins

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Abstract

Background:This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions.Methods:A cohort of 209 community-dwelling individuals without dementia aged 47-90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function.Results:SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning.Conclusions:SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.

Original languageEnglish
Pages (from-to)513-525
Number of pages13
JournalInternational Psychogeriatrics
Volume31
Issue number4
Early online date2 Oct 2018
DOIs
Publication statusPublished - Apr 2019

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Western Australia
Cognition
Dementia
Independent Living

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Sohrabi, Hamid R. ; Weinborn, Michael ; Laske, Christoph ; Bates, Kristyn A. ; Christensen, Daniel ; Taddei, Kevin ; Rainey-Smith, Stephanie R. ; Brown, Belinda M. ; Gardener, Samantha L. ; Laws, Simon M. ; Martins, Georgia ; Burnham, Samantha C. ; Bucks, Romola S. ; Reisberg, Barry ; Lautenschlager, Nicola T. ; Foster, Jonathan ; Martins, Ralph N. / Subjective memory complaints predict baseline but not future cognitive function over three years : Results from the Western Australia Memory Study. In: International Psychogeriatrics. 2019 ; Vol. 31, No. 4. pp. 513-525.
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title = "Subjective memory complaints predict baseline but not future cognitive function over three years: Results from the Western Australia Memory Study",
abstract = "Background:This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions.Methods:A cohort of 209 community-dwelling individuals without dementia aged 47-90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function.Results:SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning.Conclusions:SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.",
keywords = "Alzheimer's disease, apolipoprotein E, cognitive decline, dementia, depression, MFQ, subjective memory complaints",
author = "Sohrabi, {Hamid R.} and Michael Weinborn and Christoph Laske and Bates, {Kristyn A.} and Daniel Christensen and Kevin Taddei and Rainey-Smith, {Stephanie R.} and Brown, {Belinda M.} and Gardener, {Samantha L.} and Laws, {Simon M.} and Georgia Martins and Burnham, {Samantha C.} and Bucks, {Romola S.} and Barry Reisberg and Lautenschlager, {Nicola T.} and Jonathan Foster and Martins, {Ralph N.}",
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Sohrabi, HR, Weinborn, M, Laske, C, Bates, KA, Christensen, D, Taddei, K, Rainey-Smith, SR, Brown, BM, Gardener, SL, Laws, SM, Martins, G, Burnham, SC, Bucks, RS, Reisberg, B, Lautenschlager, NT, Foster, J & Martins, RN 2019, 'Subjective memory complaints predict baseline but not future cognitive function over three years: Results from the Western Australia Memory Study' International Psychogeriatrics, vol. 31, no. 4, pp. 513-525. https://doi.org/10.1017/S1041610218001072

Subjective memory complaints predict baseline but not future cognitive function over three years : Results from the Western Australia Memory Study. / Sohrabi, Hamid R.; Weinborn, Michael; Laske, Christoph; Bates, Kristyn A.; Christensen, Daniel; Taddei, Kevin; Rainey-Smith, Stephanie R.; Brown, Belinda M.; Gardener, Samantha L.; Laws, Simon M.; Martins, Georgia; Burnham, Samantha C.; Bucks, Romola S.; Reisberg, Barry; Lautenschlager, Nicola T.; Foster, Jonathan; Martins, Ralph N.

In: International Psychogeriatrics, Vol. 31, No. 4, 04.2019, p. 513-525.

Research output: Contribution to journalArticle

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T1 - Subjective memory complaints predict baseline but not future cognitive function over three years

T2 - Results from the Western Australia Memory Study

AU - Sohrabi, Hamid R.

AU - Weinborn, Michael

AU - Laske, Christoph

AU - Bates, Kristyn A.

AU - Christensen, Daniel

AU - Taddei, Kevin

AU - Rainey-Smith, Stephanie R.

AU - Brown, Belinda M.

AU - Gardener, Samantha L.

AU - Laws, Simon M.

AU - Martins, Georgia

AU - Burnham, Samantha C.

AU - Bucks, Romola S.

AU - Reisberg, Barry

AU - Lautenschlager, Nicola T.

AU - Foster, Jonathan

AU - Martins, Ralph N.

PY - 2019/4

Y1 - 2019/4

N2 - Background:This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions.Methods:A cohort of 209 community-dwelling individuals without dementia aged 47-90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function.Results:SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning.Conclusions:SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.

AB - Background:This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions.Methods:A cohort of 209 community-dwelling individuals without dementia aged 47-90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function.Results:SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning.Conclusions:SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.

KW - Alzheimer's disease

KW - apolipoprotein E

KW - cognitive decline

KW - dementia

KW - depression

KW - MFQ

KW - subjective memory complaints

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