Subcellular Chemical Imaging: New Avenues in Cell Biology

Johan Decelle, Giulia Veronesi, Benoit Gallet, Hryhoriy Stryhanyuk, Pietro Benettoni, Matthias Schmidt, Rémi Tucoulou, Melissa Passarelli, Sylvain Bohic, Peta Clode, Niculina Musat

    Research output: Contribution to journalReview article

    3 Citations (Scopus)

    Abstract

    To better understand the physiology and acclimation capability of the cell, one of the great challenges of the future is to access the interior of a cell and unveil its chemical landscape (composition and distribution of elements and molecules). Chemical imaging has greatly improved in sensitivity and spatial resolution to visualize and quantify nutrients, metabolites, toxic elements, and drugs in single cells at the subcellular level. This review aims to present the current potential of these emerging imaging technologies and to guide biologists towards a strategy for interrogating biological processes at the nanoscale. We also describe various solutions to combine multiple imaging techniques in a correlative way and provide perspectives and future directions for integrative subcellular imaging across different disciplines.

    Original languageEnglish
    Pages (from-to)173-188
    Number of pages16
    JournalTrends in Cell Biology
    Volume30
    Issue number3
    DOIs
    Publication statusPublished - Mar 2020

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    Decelle, J., Veronesi, G., Gallet, B., Stryhanyuk, H., Benettoni, P., Schmidt, M., ... Musat, N. (2020). Subcellular Chemical Imaging: New Avenues in Cell Biology. Trends in Cell Biology, 30(3), 173-188. https://doi.org/10.1016/j.tcb.2019.12.007