Subcellular Chemical Imaging: New Avenues in Cell Biology

Johan Decelle, Giulia Veronesi, Benoit Gallet, Hryhoriy Stryhanyuk, Pietro Benettoni, Matthias Schmidt, Rémi Tucoulou, Melissa Passarelli, Sylvain Bohic, Peta Clode, Niculina Musat

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


To better understand the physiology and acclimation capability of the cell, one of the great challenges of the future is to access the interior of a cell and unveil its chemical landscape (composition and distribution of elements and molecules). Chemical imaging has greatly improved in sensitivity and spatial resolution to visualize and quantify nutrients, metabolites, toxic elements, and drugs in single cells at the subcellular level. This review aims to present the current potential of these emerging imaging technologies and to guide biologists towards a strategy for interrogating biological processes at the nanoscale. We also describe various solutions to combine multiple imaging techniques in a correlative way and provide perspectives and future directions for integrative subcellular imaging across different disciplines.

Original languageEnglish
Pages (from-to)173-188
Number of pages16
JournalTrends in Cell Biology
Issue number3
Publication statusPublished - Mar 2020


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