Study of airway microenvironment and methods of altering the microenvironment for improved treatment of lung infections in patients with cystic fibrosis

Ramaa Puvvadi

Research output: ThesisDoctoral Thesis

103 Downloads (Pure)

Abstract

Pseudomonas aeruginosa is commonly associated with lung disease in patients with cystic fibrosis (CF). Both increased iron content and acidic airway pH are thought to contribute to pathogen colonisation. In a pilot study, adding the iron chelator calcium edetate to inhaled tobramycin was safe and both bacterial killing and lung function improved compared to tobramycin therapy alone. We measured airway pH in vivo and found no difference in pH between children with or without CF and therefore modulation of airway pH is unlikely to be a worthwhile therapy to address airway infections in CF.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Stick, Stephen, Supervisor
  • Schultz, Andre, Supervisor
  • Clements, Barry, Supervisor
  • Le Souef, Peter, Supervisor
Thesis sponsors
Award date21 Jun 2020
DOIs
Publication statusUnpublished - 2020

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