Studies of the metabolism of lipoprotein(a) in humans

Louis Ma

Research output: ThesisDoctoral Thesis

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Abstract

The studies in this thesis support the notion that Lipoprotein(a) [Lp(a)] metabolism is driven primarily by production and that catabolism plays a smaller role. The catabolic rates for the apo(a) and apoB proteins within Lp(a) particles seem to be tightly coupled. In addition, the catabolic rate is slower for Lp(a) than for LDL-apoB following apheresis, which suggests that the LDL-receptor does not play a major role in Lp(a) catabolism.These findings should be extended by investigating the kinetic associations between Lp(a) and other atherogenic lipoproteins and the mechanisms of actions of newer therapies especially apo(a) RNA based therapies.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Watts, Gerald, Supervisor
  • Chan, Dick, Supervisor
  • Barrett, Hugh, Supervisor
  • Ooi, Esther, Supervisor
Thesis sponsors
Award date24 Aug 2020
DOIs
Publication statusUnpublished - 2020

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