Studies of T cell and B cell dysfunction induced by IFN-α in HIV-1 infection

Lilian Chun Cha

Studies of T cell and B cell dysfunction induced by IFN-α in HIV-1 infection

Lilian Chun Cha

Research output: Thesis › Doctoral Thesis

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Abstract

HIV infection causes numerical and functional defects of T and B cells and although antiretroviral therapy corrects many of these defects, some persist. The effects of immune activation mediated by the cytokine, interferon (IFN)-a, are implicated and were investigated here. IFN-a inhibited interleukin (IL)-7-mediated proliferation of T cells but this was not attributed to inhibition of the STAT5 signalling pathway that is induced by IL-7. IFN-a also inhibited IL-21-induced production of lgG antibodies by B cells via impairment of phosphorylation of STAT3. These findings confirm that IFN-a impacts upon key processes necessary for T and B cell recovery and function.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Fernandez, Sonia, Supervisor French, Martyn, Supervisor
Award date	22 Dec 2016
Publication status	Unpublished - 2016

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SDG 3 Good Health and Well-being

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THESIS - DOCTOR OF PHILOSOPHY - CHA Lilian Chun - 2016
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title = "Studies of T cell and B cell dysfunction induced by IFN-α in HIV-1 infection",

abstract = "HIV infection causes numerical and functional defects of T and B cells and although antiretroviral therapy corrects many of these defects, some persist. The effects of immune activation mediated by the cytokine, interferon (IFN)-a, are implicated and were investigated here. IFN-a inhibited interleukin (IL)-7-mediated proliferation of T cells but this was not attributed to inhibition of the STAT5 signalling pathway that is induced by IL-7. IFN-a also inhibited IL-21-induced production of lgG antibodies by B cells via impairment of phosphorylation of STAT3. These findings confirm that IFN-a impacts upon key processes necessary for T and B cell recovery and function.",

keywords = "HIV, T cells, B cells, Immune activation, Interferon-a",

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year = "2016",

language = "English",

school = "The University of Western Australia",

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TY - BOOK

T1 - Studies of T cell and B cell dysfunction induced by IFN-α in HIV-1 infection

AU - Cha, Lilian Chun

PY - 2016

Y1 - 2016

N2 - HIV infection causes numerical and functional defects of T and B cells and although antiretroviral therapy corrects many of these defects, some persist. The effects of immune activation mediated by the cytokine, interferon (IFN)-a, are implicated and were investigated here. IFN-a inhibited interleukin (IL)-7-mediated proliferation of T cells but this was not attributed to inhibition of the STAT5 signalling pathway that is induced by IL-7. IFN-a also inhibited IL-21-induced production of lgG antibodies by B cells via impairment of phosphorylation of STAT3. These findings confirm that IFN-a impacts upon key processes necessary for T and B cell recovery and function.

AB - HIV infection causes numerical and functional defects of T and B cells and although antiretroviral therapy corrects many of these defects, some persist. The effects of immune activation mediated by the cytokine, interferon (IFN)-a, are implicated and were investigated here. IFN-a inhibited interleukin (IL)-7-mediated proliferation of T cells but this was not attributed to inhibition of the STAT5 signalling pathway that is induced by IL-7. IFN-a also inhibited IL-21-induced production of lgG antibodies by B cells via impairment of phosphorylation of STAT3. These findings confirm that IFN-a impacts upon key processes necessary for T and B cell recovery and function.

KW - HIV

KW - T cells

KW - B cells

KW - Immune activation

KW - Interferon-a

M3 - Doctoral Thesis

ER -

Studies of T cell and B cell dysfunction induced by IFN-α in HIV-1 infection

Abstract

UN SDGs

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