The thesis studied an immune system receptor called KIR2DL4, which resides on the surface of natural killer cells. KIR2DL4 was widely believed to interact with another molecule, HLA-G, and this interaction was thought critical to the acceptance of transplanted organs, for allowing a mother's immune system to accept a newly fertilized embryo, and in damping down otherwise harmful autoimmune responses. However, the results of this thesis overturned this idea by demonstrating that HLA-G and KIR2DL4 do NOT interact with each other. This finding sets a foundation for future studies aiming to find the true binding partner of KIR2DL4.
|Qualification||Doctor of Philosophy|
|Award date||23 Mar 2017|
|Publication status||Unpublished - 2016|