Studies of KIR2DL4 and HLA-G

Michael Eric Lewis Le Page

    Research output: ThesisDoctoral Thesis

    343 Downloads (Pure)


    The thesis studied an immune system receptor called KIR2DL4, which resides on the surface of natural killer cells. KIR2DL4 was widely believed to interact with another molecule, HLA-G, and this interaction was thought critical to the acceptance of transplanted organs, for allowing a mother's immune system to accept a newly fertilized embryo, and in damping down otherwise harmful autoimmune responses. However, the results of this thesis overturned this idea by demonstrating that HLA-G and KIR2DL4 do NOT interact with each other. This finding sets a foundation for future studies aiming to find the true binding partner of KIR2DL4.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    • Witt, Campbell, Supervisor
    • Christiansen, Frank, Supervisor
    • Allcock, Richard, Supervisor
    Award date23 Mar 2017
    Publication statusUnpublished - 2016


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