Projects per year
Abstract
The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases. Strong experimental evidence supports the existence of membrane microdomains in osteoclasts (OCs). However, the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized. Membrane microdomain components, such as scaffolding proteins and the actin cytoskeleton, as well as the roles of individual membrane proteins, need to be elucidated. In this review, we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle.
Original language | English |
---|---|
Article number | 61 |
Journal | Bone Research |
Volume | 11 |
Issue number | 1 |
DOIs | |
Publication status | Published - Dec 2023 |
Fingerprint
Dive into the research topics of 'Structure and function of the membrane microdomains in osteoclasts'. Together they form a unique fingerprint.Projects
- 2 Finished
-
‘Sorting-Out’ the molecular link between SNX10 and Autophagy in Osteoclasts
Xu, J. (Investigator 01), Pavlos, N. (Investigator 02) & Tickner, J. (Investigator 03)
NHMRC National Health and Medical Research Council
1/01/19 → 31/12/22
Project: Research
-
Furin: Carving-up vital substrates for bone remodelling and homeostasis
Xu, J. (Investigator 01), Pavlos, N. (Investigator 02) & Tickner, J. (Investigator 03)
NHMRC National Health and Medical Research Council
1/01/16 → 31/12/19
Project: Research