TY - JOUR
T1 - Structural white matter properties and cognitive resilience to tau pathology
AU - PREVENT‐AD Research Group
AU - Qiu, Ting
AU - Liu, Zhen Qi
AU - Rheault, François
AU - Legarreta, Jon Haitz
AU - Valcourt Caron, Alex
AU - St-Onge, Frédéric
AU - Strikwerda-Brown, Cherie
AU - Metz, Amelie
AU - Dadar, Mahsa
AU - Soucy, Jean Paul
AU - Pichet Binette, Alexa
AU - Spreng, R. Nathan
AU - Descoteaux, Maxime
AU - Villeneuve, Sylvia
N1 - Publisher Copyright:
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024/5
Y1 - 2024/5
N2 - INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties. RESULTS: Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascular risk factors were associated with white matter properties of both networks. DISCUSSION: White matter can influence cognitive resilience against tau pathology, and promoting education and vascular health may enhance optimal white matter properties. Highlights: Aβ and tau were associated with longitudinal memory change over ∼7.5 years. White matter properties attenuated the impact of tau pathology on memory change. Health/risk factors were associated with white matter properties.
AB - INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties. RESULTS: Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascular risk factors were associated with white matter properties of both networks. DISCUSSION: White matter can influence cognitive resilience against tau pathology, and promoting education and vascular health may enhance optimal white matter properties. Highlights: Aβ and tau were associated with longitudinal memory change over ∼7.5 years. White matter properties attenuated the impact of tau pathology on memory change. Health/risk factors were associated with white matter properties.
KW - amyloid-β
KW - cognitive resilience
KW - default mode network
KW - limbic network
KW - tau
KW - white matter
UR - http://www.scopus.com/inward/record.url?scp=85189642964&partnerID=8YFLogxK
U2 - 10.1002/alz.13776
DO - 10.1002/alz.13776
M3 - Article
C2 - 38561254
AN - SCOPUS:85189642964
SN - 1552-5260
VL - 20
SP - 3364
EP - 3377
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 5
ER -