Structural Study of Dehydrocurvularin, an Inhibitor of Microtubule Assembly

F Almassi, Emilio Ghisalberti, Brian Skelton, Allan White

Research output: Contribution to journalArticlepeer-review


The solid-state structure of the fungal metabolite E-dehydrocurvularin (2), an inhibitor of microtubule assembly, has been determined by a single-crystal room-temperature X-ray study for comparison with curvularin (1). Crystals of (2) are orthorhombic, P2(1)2(1)2(1), a 17 . 757(9), b 10.031(6), c 8.069(4) angstrom, z = 4, R was 0.060 for 988 independent 'observed' [I > 3sigma(I)] diffractometer reflections. The results of this study show that (1) and (2) adopt opposite helicity in the solid state.
Original languageEnglish
Pages (from-to)1193-1197
JournalAustralian Journal of Chemistry: an international journal for chemical science
Publication statusPublished - 1994


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