The solid-state structure of the fungal metabolite E-dehydrocurvularin (2), an inhibitor of microtubule assembly, has been determined by a single-crystal room-temperature X-ray study for comparison with curvularin (1). Crystals of (2) are orthorhombic, P2(1)2(1)2(1), a 17 . 757(9), b 10.031(6), c 8.069(4) angstrom, z = 4, R was 0.060 for 988 independent 'observed' [I > 3sigma(I)] diffractometer reflections. The results of this study show that (1) and (2) adopt opposite helicity in the solid state.
|Journal||Australian Journal of Chemistry: an international journal for chemical science|
|Publication status||Published - 1994|
Almassi, F., Ghisalberti, E., Skelton, B., & White, A. (1994). Structural Study of Dehydrocurvularin, an Inhibitor of Microtubule Assembly. Australian Journal of Chemistry: an international journal for chemical science, 47, 1193-1197. https://doi.org/10.1071/CH9941193