The Golden Mile in the 2.7 Ga Eastern Goldfields Province of the Yilgarn Craton, Western Australia, has produced 385 million tonnes of ore at a head grade of 5.23 g/t gold (1893–2016). Gold-pyrite ore bodies (Fimiston Lodes) trace kilometre-scale shear zone systems centred on the D2 Golden Mile Fault, one of three northwest striking sinistral strike-slip faults segmenting upright D1 folds. The Fimiston shear zones formed as D2a Riedel systems in greenschist-facies (actinolite-albite) tholeiitic rocks, the 700-m-thick Golden Mile Dolerite (GMD) sill and the Paringa Basalt (PB), during left-lateral displacement of up to 12 km on the D2 master faults. Pre-mineralisation granodiorite dykes were emplaced into the D2 shear zones at 2674 ± 6 Ma, and syn-mineralisation diorite porphyries at 2663 ± 11 Ma. The widespread infiltration of hydrothermal fluid generated chlorite-calcite and muscovite-ankerite alteration in the Golden Mile, and paragonite-ankerite-chloritoid alteration southeast of the deposit. Fluid infiltration reactivated the D2 shear zones causing post-porphyry displacement of up to 30 m at principal Fimiston Lodes moving the southwest block down and southeast along lines pitching 20°SE. D3 reverse faulting at the southwest dipping GMD-PB contact of the D1 Kalgoorlie Anticline formed the 1.3-km-long Oroya Shoot during late gold-telluride mineralisation. Syn-mineralisation D3a reverse faulting alternated with periods of sinistral strike-slip (D2c) until ENE-WSW shortening prevailed and was accommodated by barren D3b thrusts. North-striking D4 strike-slip faults of up to 2 km dextral displacement crosscut the Fimiston Lodes and the barren thrusts, and control gold-pyrite quartz vein ore at Mt. Charlotte (2651 ± 9 Ma).