Structural requirements for anti-oxidant activity of calix[n]arenes and their associated anti-bacterial activity

Elizabeth Stephens; Y. Tauran; A.W. Coleman; Melinda Fitzgerald

doi:10.1039/c4cc08576k

Structural requirements for anti-oxidant activity of calix[n]arenes and their associated anti-bacterial activity

Elizabeth Stephens, Y. Tauran, A.W. Coleman, Melinda Fitzgerald

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Abstract

© 2015 The Royal Society of Chemistry. Treatment of neural cells with calix[n]arenes featuring sulphonate moieties and linked to Ag nanoparticles results in reduced reactive species. For Gram+ bacteria there is an inverse correlation between anti-bacterial activity and ROS reduction whereas for Gram- bacteria only calix[6]arenes bearing O-alkyl sulphonate functions act as ROS inhibitors and anti-bacterial agents.

Original language	English
Pages (from-to)	851-854
Journal	Chemical Communications
Volume	51
Issue number	5
DOIs	https://doi.org/10.1039/c4cc08576k
Publication status	Published - 2015

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Stephens, E., Tauran, Y., Coleman, A. W., & Fitzgerald, M. (2015). Structural requirements for anti-oxidant activity of calix[n]arenes and their associated anti-bacterial activity. Chemical Communications, 51(5), 851-854. https://doi.org/10.1039/c4cc08576k

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AB - © 2015 The Royal Society of Chemistry. Treatment of neural cells with calix[n]arenes featuring sulphonate moieties and linked to Ag nanoparticles results in reduced reactive species. For Gram+ bacteria there is an inverse correlation between anti-bacterial activity and ROS reduction whereas for Gram- bacteria only calix[6]arenes bearing O-alkyl sulphonate functions act as ROS inhibitors and anti-bacterial agents.

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10.1039/c4cc08576k