Structural composition of airway wall fat in healthy weight and overweight/obese subjects

Carolyn J. Wang; Peter B. Noble; Jack S. Logan; Alvenia Cairncross; Alan L. James; John G. Elliot; Kimberley C.W. Wang

doi:10.1183/13993003.01772-2024

Structural composition of airway wall fat in healthy weight and overweight/obese subjects

Research output: Contribution to journal › Article › peer-review

Abstract

Obesity is a leading risk factor for severe asthma, where patients experience recurrent exacerbations and frequent hospitalisations [1]. Reduced lung function in these individuals is potentially driven by extra-thoracic and abdominal adiposity compressing the chest cavity, or through adipokines circulated from visceral and subcutaneous adipose tissues that exacerbate airway inflammation [2]. We identified airway-associated adipose tissue as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines [3, 4] that may adversely affect lung function.

Original language	English
Article number	2401772
Number of pages	4
Journal	European Respiratory Journal
Volume	65
Issue number	2
DOIs	https://doi.org/10.1183/13993003.01772-2024
Publication status	Published - Feb 2025

Funding

Funders	Funder number
NHMRC National Health and Medical Research Council	1063068, 513842

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1183/13993003.01772-2024

Airway Extracellular Matrix and Smooth Muscle in COPD
James, A. (Investigator 01), King, G. (Investigator 02), Noble, P. (Investigator 03), McFawn, P. (Investigator 04) & McParland, B. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/14 → 30/11/18
Project: Research
Response of Human Airways to Deep Inflation in Health and Disease
McFawn, P. (Chief Investigator), Noble, P. (Chief Investigator), Mitchell, H. (Chief Investigator) & James, A. (Chief Investigator)
NHMRC Project Grants
1/01/08 → 31/12/12
Project: Research

Cite this

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title = "Structural composition of airway wall fat in healthy weight and overweight/obese subjects",

abstract = "Obesity is a leading risk factor for severe asthma, where patients experience recurrent exacerbations and frequent hospitalisations [1]. Reduced lung function in these individuals is potentially driven by extra-thoracic and abdominal adiposity compressing the chest cavity, or through adipokines circulated from visceral and subcutaneous adipose tissues that exacerbate airway inflammation [2]. We identified airway-associated adipose tissue as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines [3, 4] that may adversely affect lung function.",

author = "Wang, \{Carolyn J.\} and Noble, \{Peter B.\} and Logan, \{Jack S.\} and Alvenia Cairncross and James, \{Alan L.\} and Elliot, \{John G.\} and Wang, \{Kimberley C.W.\}",

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doi = "10.1183/13993003.01772-2024",

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AU - Wang, Carolyn J.

AU - Noble, Peter B.

AU - Logan, Jack S.

AU - Cairncross, Alvenia

AU - James, Alan L.

AU - Elliot, John G.

AU - Wang, Kimberley C.W.

PY - 2025/2

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N2 - Obesity is a leading risk factor for severe asthma, where patients experience recurrent exacerbations and frequent hospitalisations [1]. Reduced lung function in these individuals is potentially driven by extra-thoracic and abdominal adiposity compressing the chest cavity, or through adipokines circulated from visceral and subcutaneous adipose tissues that exacerbate airway inflammation [2]. We identified airway-associated adipose tissue as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines [3, 4] that may adversely affect lung function.

AB - Obesity is a leading risk factor for severe asthma, where patients experience recurrent exacerbations and frequent hospitalisations [1]. Reduced lung function in these individuals is potentially driven by extra-thoracic and abdominal adiposity compressing the chest cavity, or through adipokines circulated from visceral and subcutaneous adipose tissues that exacerbate airway inflammation [2]. We identified airway-associated adipose tissue as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines [3, 4] that may adversely affect lung function.

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DO - 10.1183/13993003.01772-2024

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JO - European Respiratory Journal

JF - European Respiratory Journal

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Structural composition of airway wall fat in healthy weight and overweight/obese subjects

Abstract

Funding

UN SDGs

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Projects

Airway Extracellular Matrix and Smooth Muscle in COPD

Response of Human Airways to Deep Inflation in Health and Disease

Cite this