Structural composition of airway wall fat in healthy weight and overweight/obese subjects

Carolyn J. Wang; Peter B. Noble; Jack S. Logan; Alvenia Cairncross; Alan L. James; John G. Elliot; Kimberley C.W. Wang

doi:10.1183/13993003.01772-2024

Structural composition of airway wall fat in healthy weight and overweight/obese subjects

Carolyn J. Wang, Peter B. Noble, Jack S. Logan, Alvenia Cairncross, Alan L. James, John G. Elliot, Kimberley C.W. Wang

Research output: Contribution to journal › Letter › peer-review

Abstract

Obesity is a leading risk factor for severe asthma, where patients experience recurrent exacerbations and frequent hospitalisations [1]. Reduced lung function in these individuals is potentially driven by extra-thoracic and abdominal adiposity compressing the chest cavity, or through adipokines circulated from visceral and subcutaneous adipose tissues that exacerbate airway inflammation [2]. We identified airway-associated adipose tissue as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines [3, 4] that may adversely affect lung function.

Original language	English
Article number	2401772
Number of pages	4
Journal	European Respiratory Journal
Volume	65
Issue number	2
DOIs	https://doi.org/10.1183/13993003.01772-2024
Publication status	Published - Feb 2025

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10.1183/13993003.01772-2024

Airway Extracellular Matrix and Smooth Muscle in COPD
James, A. (Investigator 01), King, G. (Investigator 02), Noble, P. (Investigator 03), McFawn, P. (Investigator 04) & McParland, B. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/14 → 30/11/18
Project: Research
Response of Human Airways to Deep Inflation in Health and Disease
McFawn, P. (Chief Investigator), Noble, P. (Chief Investigator), Mitchell, H. (Chief Investigator) & James, A. (Chief Investigator)
NHMRC Project Grants
1/01/08 → 31/12/12
Project: Research

Cite this

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title = "Structural composition of airway wall fat in healthy weight and overweight/obese subjects",

abstract = "Obesity is a leading risk factor for severe asthma, where patients experience recurrent exacerbations and frequent hospitalisations [1]. Reduced lung function in these individuals is potentially driven by extra-thoracic and abdominal adiposity compressing the chest cavity, or through adipokines circulated from visceral and subcutaneous adipose tissues that exacerbate airway inflammation [2]. We identified airway-associated adipose tissue as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines [3, 4] that may adversely affect lung function.",

author = "Wang, {Carolyn J.} and Noble, {Peter B.} and Logan, {Jack S.} and Alvenia Cairncross and James, {Alan L.} and Elliot, {John G.} and Wang, {Kimberley C.W.}",

year = "2025",

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doi = "10.1183/13993003.01772-2024",

language = "English",

volume = "65",

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T1 - Structural composition of airway wall fat in healthy weight and overweight/obese subjects

AU - Wang, Carolyn J.

AU - Noble, Peter B.

AU - Logan, Jack S.

AU - Cairncross, Alvenia

AU - James, Alan L.

AU - Elliot, John G.

AU - Wang, Kimberley C.W.

PY - 2025/2

Y1 - 2025/2

N2 - Obesity is a leading risk factor for severe asthma, where patients experience recurrent exacerbations and frequent hospitalisations [1]. Reduced lung function in these individuals is potentially driven by extra-thoracic and abdominal adiposity compressing the chest cavity, or through adipokines circulated from visceral and subcutaneous adipose tissues that exacerbate airway inflammation [2]. We identified airway-associated adipose tissue as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines [3, 4] that may adversely affect lung function.

AB - Obesity is a leading risk factor for severe asthma, where patients experience recurrent exacerbations and frequent hospitalisations [1]. Reduced lung function in these individuals is potentially driven by extra-thoracic and abdominal adiposity compressing the chest cavity, or through adipokines circulated from visceral and subcutaneous adipose tissues that exacerbate airway inflammation [2]. We identified airway-associated adipose tissue as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines [3, 4] that may adversely affect lung function.

U2 - 10.1183/13993003.01772-2024

DO - 10.1183/13993003.01772-2024

M3 - Letter

C2 - 39947686

SN - 0903-1936

VL - 65

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 2

M1 - 2401772

ER -

Structural composition of airway wall fat in healthy weight and overweight/obese subjects

Abstract

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Projects

Airway Extracellular Matrix and Smooth Muscle in COPD

Response of Human Airways to Deep Inflation in Health and Disease

Cite this