Structural characterisation of lipid a phosphoethanolamine transferase from Neisseria species

Anandhi Anandan

Research output: ThesisDoctoral Thesis

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Abstract

Gram-negative bacteria gain resistance by modifying the lipid A moiety present on their outer membrane. One such modification is the addition of phosphoethanolamine to lipidA brought about by an enzyme called lipid A phosphoethanolamine transferase (EptA). The crystal structure of EptA was determined revealing a helical transmembrane domain linked to a periplasmicfacing soluble domain with the active site comprising residues from both domains. Biophysical studies suggest the enzyme adopts multiple conformations essential for binding two different sized lipid substrates. This study will aid in the design of novel therapeutic agents for the treatment of antimicrobial resistant bacterial infections.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date18 Sep 2018
DOIs
Publication statusUnpublished - 2018

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