Structural characterisation of capsular transporter proteins from Neisseria meningitidis

Lorelei Masselot--Joubert

Research output: ThesisDoctoral Thesis

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Abstract

Neisseria meningitidis (Nm) uses a polysaccharide capsule to protect itself and escape the immune system. Polysaccharide transporters are complexes inserted into bacterial membranes exporting polysaccharides, of which the Nm ABC-transporter-dependent system (CtrA, CtrB, CtrC and CtrD) is one. This thesis presents: the crystallographic structure of CtrC (transmembrane domain of the ABC transporter), the low-resolution TEM structure of CtrB (polysaccharide co-polymerase protein) in detergent, the interactions between CtrB and CtrC and the CtrB/CtrC low-resolution TEM structure in circularised nanodiscs.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Vrielink, Alice, Supervisor
  • Bond, Charlie, Supervisor
  • Kahler, Charlene, Supervisor
  • Landsberg, Michael J., Supervisor, External person
Thesis sponsors
Award date27 Jun 2023
DOIs
Publication statusUnpublished - 2023

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