TY - JOUR
T1 - Stromelysin-1 (MMP-3) gene 5A/6A promoter polymorphism is associated with blood pressure in a community population
AU - Beilby, John
AU - Chapman, Caroline
AU - Palmer, Lyle
AU - Mcquillan, Brendan
AU - Thompson, Peter
AU - Hung, Joe
PY - 2005
Y1 - 2005
N2 - Background and objectives Arterial remodelling contributes to the development of hypertension. Stromelysin-1 (MMP-3), a member of the matrix metalloproteinase family may contribute to this process. Stromelysin-1 gene expression is partly regulated by a common polymorphism in the promoter region of either five or six consecutive adenosine bases (5A/6A).Methods and results A cross-sectional study of 1111 randomly selected male and female community subjects (27-77 years), were assessed for conventional cardiovascular risk factors and stromelysin-1. 5A-1171-6A genotype. Multivariate analysis showed an independent association between the stromelysin-1 genotype and blood pressure that was recessive for the 5A/5A genotype. Subjects with the 5A/5A genotype had a higher mean systolic blood pressure (SBP) (+4.2 mmHg) and diastolic blood pressure (DBP) (+2.2 mmHg) compared to subjects with 5A/6A and 6A/6A genotypes. Subgroup analysis revealed an independent association of the 5A/5A genotype with SBP (+3.6 mmHg, P=0.001) and DBP (+2.0 mmHg, P = 0.004) in subjects not on blood pressure medication. Whereas subjects with the 5A/5A genotype and taking medication had a higher mean SBP (+7.4 mmHg, P=0.02) and DBP (+2.7 mmHg, P=0.11). Multivariate analysis in the whole population showed there was no association between genotypes and mean intimal-medial wall thickness (IMT) (P=0.87) or the likelihood of carotid plaque formation.Conclusions The stromelysin-1 5A-1171-6A genotype is an important determinant of blood pressure in this general population sample. © 2005 Lippincott Williams C Wilkins.
AB - Background and objectives Arterial remodelling contributes to the development of hypertension. Stromelysin-1 (MMP-3), a member of the matrix metalloproteinase family may contribute to this process. Stromelysin-1 gene expression is partly regulated by a common polymorphism in the promoter region of either five or six consecutive adenosine bases (5A/6A).Methods and results A cross-sectional study of 1111 randomly selected male and female community subjects (27-77 years), were assessed for conventional cardiovascular risk factors and stromelysin-1. 5A-1171-6A genotype. Multivariate analysis showed an independent association between the stromelysin-1 genotype and blood pressure that was recessive for the 5A/5A genotype. Subjects with the 5A/5A genotype had a higher mean systolic blood pressure (SBP) (+4.2 mmHg) and diastolic blood pressure (DBP) (+2.2 mmHg) compared to subjects with 5A/6A and 6A/6A genotypes. Subgroup analysis revealed an independent association of the 5A/5A genotype with SBP (+3.6 mmHg, P=0.001) and DBP (+2.0 mmHg, P = 0.004) in subjects not on blood pressure medication. Whereas subjects with the 5A/5A genotype and taking medication had a higher mean SBP (+7.4 mmHg, P=0.02) and DBP (+2.7 mmHg, P=0.11). Multivariate analysis in the whole population showed there was no association between genotypes and mean intimal-medial wall thickness (IMT) (P=0.87) or the likelihood of carotid plaque formation.Conclusions The stromelysin-1 5A-1171-6A genotype is an important determinant of blood pressure in this general population sample. © 2005 Lippincott Williams C Wilkins.
U2 - 10.1097/01.hjh.0000160209.48479.ae
DO - 10.1097/01.hjh.0000160209.48479.ae
M3 - Article
SN - 0263-6352
VL - 23
SP - 537
EP - 542
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 3
ER -