Stromal endocrine cell micronests associated with an ovarian mucinous cystadenoma: Endocrine cell preservation (Pseudohyperplasia) Potentially mimicking stromal sex cord proliferation or tumor microinvasion

Colin J.R. Stewart, Steve Harding

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Endocrine cell micronests (ECMs) have been described only twice previously in the ovary, both in association with mucinous neoplasms exhibiting intraepithelial endocrine cell hyperplasia. We report a 31-yr-old patient with a mucinous cystadenoma in which ECMs were distributed in the stroma surrounding degenerate glandular elements. Immunohistochemistry demonstrated only sparse endocrine cells within the neoplastic glands. We postulate that the ECMs in this case reflected relative preservation of endocrine elements in the context of epithelial atrophy, a process more commonly encountered in gastrointestinal pathology. Ovarian ECMs should also be distinguished from stromal sex cord proliferations and tumor microinvasion.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalInternational Journal of Gynecological Pathology
Volume40
Issue number1
Early online date1 Nov 2019
DOIs
Publication statusPublished - Jan 2021

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