TY - JOUR
T1 - Streptococcus pyogenes adhesion and colonization
AU - Brouwer, Stephan
AU - Barnett, Timothy C
AU - Rivera-Hernandez, Tania
AU - Rohde, Manfred
AU - Walker, Mark J
N1 - © 2016 Federation of European Biochemical Societies.
PY - 2016/11
Y1 - 2016/11
N2 - Streptococcus pyogenes (group A Streptococcus, GAS) is a human-adapted pathogen responsible for a wide spectrum of disease. GAS can cause relatively mild illnesses, such as strep throat or impetigo, and less frequent but severe life-threatening diseases such as necrotizing fasciitis and streptococcal toxic shock syndrome. GAS is an important public health problem causing significant morbidity and mortality worldwide. The main route of GAS transmission between humans is through close or direct physical contact, and particularly via respiratory droplets. The upper respiratory tract and skin are major reservoirs for GAS infections. The ability of GAS to establish an infection in the new host at these anatomical sites primarily results from two distinct physiological processes, namely bacterial adhesion and colonization. These fundamental aspects of pathogenesis rely upon a variety of GAS virulence factors, which are usually under strict transcriptional regulation. Considerable progress has been made in better understanding these initial infection steps. This review summarizes our current knowledge of the molecular mechanisms of GAS adhesion and colonization.
AB - Streptococcus pyogenes (group A Streptococcus, GAS) is a human-adapted pathogen responsible for a wide spectrum of disease. GAS can cause relatively mild illnesses, such as strep throat or impetigo, and less frequent but severe life-threatening diseases such as necrotizing fasciitis and streptococcal toxic shock syndrome. GAS is an important public health problem causing significant morbidity and mortality worldwide. The main route of GAS transmission between humans is through close or direct physical contact, and particularly via respiratory droplets. The upper respiratory tract and skin are major reservoirs for GAS infections. The ability of GAS to establish an infection in the new host at these anatomical sites primarily results from two distinct physiological processes, namely bacterial adhesion and colonization. These fundamental aspects of pathogenesis rely upon a variety of GAS virulence factors, which are usually under strict transcriptional regulation. Considerable progress has been made in better understanding these initial infection steps. This review summarizes our current knowledge of the molecular mechanisms of GAS adhesion and colonization.
KW - Bacterial Adhesion
KW - Bacterial Proteins/metabolism
KW - Biofilms
KW - Humans
KW - Respiratory System/microbiology
KW - Skin/microbiology
KW - Streptococcal Infections/microbiology
KW - Streptococcus pyogenes/physiology
UR - http://www.scopus.com/inward/record.url?scp=84979017217&partnerID=8YFLogxK
U2 - 10.1002/1873-3468.12254
DO - 10.1002/1873-3468.12254
M3 - Review article
C2 - 27312939
VL - 590
SP - 3739
EP - 3757
JO - Federation of European Biochemical Societies Letters
JF - Federation of European Biochemical Societies Letters
SN - 0014-5793
IS - 21
ER -