Streptococcal toxins: role in pathogenesis and disease

Timothy C Barnett, Jason N Cole, Tania Rivera-Hernandez, Anna Henningham, James C Paton, Victor Nizet, Mark J Walker

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Group A Streptococcus (Streptococcus pyogenes), group B Streptococcus (Streptococcus agalactiae) and Streptococcus pneumoniae (pneumococcus) are host-adapted bacterial pathogens among the leading infectious causes of human morbidity and mortality. These microbes and related members of the genus Streptococcus produce an array of toxins that act against human cells or tissues, resulting in impaired immune responses and subversion of host physiological processes to benefit the invading microorganism. This toxin repertoire includes haemolysins, proteases, superantigens and other agents that ultimately enhance colonization and survival within the host and promote dissemination of the pathogen.

Original languageEnglish
Pages (from-to)1721-41
Number of pages21
JournalCellular Microbiology
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 2015
Externally publishedYes

Take-down notice

© 2015 John Wiley & Sons Ltd.

Fingerprint Dive into the research topics of 'Streptococcal toxins: role in pathogenesis and disease'. Together they form a unique fingerprint.

Cite this