In order to achieve an effective balance between plasticity and strength, a group of Ti-26Nb-xZr-yMn (x = 4, 7, 10 wt% and y = 3, 5 wt%) alloys were designed to evaluate the effects of Mn and Zr on the microstructures, mechanical properties and strengthening effects of the Ti[sbnd]Nb system. All the investigated alloys illustrate a monolithic β phase in their microstructure and they all possess substantial true plasticity (~160%) and true maximum strength (~ 950 MPa) without fracture during the compression tests within the load capacity of 100 kN. The contribution of solid-solution, grain-boundary and dislocation strengthening mechanisms have been evaluated using the strengthening model for β Ti alloys for all the investigated alloys. Among the investigated alloys, Ti-26Nb-4Zr-5Mn demonstrates the highest true yield strength (654 MPa), dislocation density (2.45 × 1015 m− 2) and hardness (242 HV) along with improved strain hardening ability in terms of strain hardening indices (0.42 and 0.09). Furthermore, based on the superior mechanical properties among the investigated alloys, the electrochemical performance of Ti-26Nb-4Zr-3Mn and Ti-26Nb-4Zr-5Mn have also been analyzed in this work. The electrochemical measurements show that both alloys have almost similar corrosion potential and corrosion current density in simulated body fluid, i.e., −0.45 V and 0.838 nA/cm2 for Ti-26Nb-4Zr-3Mn, −0.48 V and 0.839 nA/cm2 for Ti-26Nb-4Zr-5Mn, respectively.