Strain and elasticity imaging in compression optical coherence elastography: The two-decade perspective and recent advances

Vladimir Y. Zaitsev, Alexander L. Matveyev, Lev A. Matveev, Alexander A. Sovetsky, Matt S. Hepburn, Alireza Mowla, Brendan F. Kennedy

Research output: Contribution to journalReview articlepeer-review

81 Citations (Scopus)

Abstract

Quantitative mapping of deformation and elasticity in optical coherence tomography has attracted much attention of researchers during the last two decades. However, despite intense effort it took ~15 years to demonstrate optical coherence elastography (OCE) as a practically useful technique. Similarly to medical ultrasound, where elastography was first realized using the quasi-static compression principle and later shear-wave-based systems were developed, in OCE these two approaches also developed in parallel. However, although the compression OCE (C-OCE) was proposed historically earlier in the seminal paper by J. Schmitt in 1998, breakthroughs in quantitative mapping of genuine local strains and the Young's modulus in C-OCE have been reported only recently and have not yet obtained sufficient attention in reviews. In this overview, we focus on underlying principles of C-OCE; discuss various practical challenges in its realization and present examples of biomedical applications of C-OCE. The figure demonstrates OCE-visualization of complex transient strains in a corneal sample heated by an infrared laser beam.

Original languageEnglish
Article numbere202000257
JournalJournal of Biophotonics
Volume14
Issue number2
Early online date4 Aug 2020
DOIs
Publication statusPublished - Feb 2021

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